WeChat assisted electronic symptom measurement for patients with adenomyosis

作者全名：Xu, Wei; Zhang, Xin; Xu, Fan; Yuan, Yuan; Tang, Ying; Shi, Qiuling

作者地址：[Xu, Wei; Shi, Qiuling] Chongqing Med Univ, Coll Publ Hlth, Chongqing, Peoples R China; [Zhang, Xin; Shi, Qiuling] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Xu, Fan; Tang, Ying] North Sichuan Med Univ, Nanchong Cent Hosp, Clin Med Coll 2, Dept Obstet & Gynecol, Nanchong, Sichuan, Peoples R China; [Yuan, Yuan] Southwest Med Univ, Affiliated Hosp, Dept Obstet & Gynecol, Luzhou, Sichuan, Peoples R China

通信作者：Shi, QL (通讯作者)，Chongqing Med Univ, Coll Publ Hlth, Chongqing, Peoples R China.; Shi, QL (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China.

来源：BMC MEDICAL INFORMATICS AND DECISION MAKING

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001250978400003

JCR分区：Q2

影响因子：3.3

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Electronic PRO-based symptom management; Adenomyosis; WeChat group-based doctor-patient communication; Patient-reported outcomes; Validity; Symptom burden

摘要：Purpose Symptom assessment is central to appropriate adenomyosis management. Using a WeChat mini-program-based portal, we aimed to establish a valid symptom assessment scale of adenomyosis (AM-SAS) to precisely and timely identify needs of symptom management and ultimately, to alert disease recurrence. Methods A combination of intensive interviews of patients with adenomyosis and natural language processing on WeChat clinician-patient group communication was used to generate a pool of symptom items-related to adenomyosis. An expert panel shortened the list to form the provisional AM-SAS. The AM-SAS was built in a Wechat mini-programmer and sent to patients to exam the psychotically validity and clinical applicability through classic test theory and item response theory. Results Total 338 patients with adenomyosis (29 for interview, 179 for development, and 130 for external validation) and 86 gynecologists were included. The over 90% compliance to the WeChat-based symptom evaluate. The AM-SAS demonstrated the uni-dimensionality through Rasch analysis, good internal consistency (all Cronbach's alphas above 0.8), and test-retest reliability (intraclass correlation coefficients ranging from 0.65 to 0.84). Differences symptom severity score between patients in the anemic and normal hemoglobin groups (3.04 +/- 3.17 vs. 5.68 +/- 3.41, P < 0.001). In external validation, AM-SAS successfully detected differences in symptom burden and physical status between those with or without relapse. Conclusion Electronic PRO-based AM-SAS is a valuable instrument for monitoring AM-related symptoms. As an outcome measure of multiple symptoms in clinical trials, the AM-SAS may identify patients who need extensive care after discharge and capture significant beneficial changes of patients may have been overlooked.

基金机构：Chongqing social Science Planning Project

基金资助正文：We would like to thank Mingtao Yang, Ling Qian, Xueyao Su, Ruoyan Gong, Qingsong Yu, Hongfan Yu, Yang Pu, Xuemei Zheng, Xiaogang Zhu for their contributions to the data collection and expert opinion in this study.