Processed Polygonatum cyrtonema Hua attenuates postpartum depression in rat model by regulating monoamines and hormones
作者全名：Zhu, Xiao-hong; Zhang, Jia-li; Li, De-hua; Wang, Zhong-qiang; Liu, Yan-ku; Fan, Jing-xian; Jiang, Shang-ren; Li, Xin-ran; He, Xian-yuan
作者地址：[Zhu, Xiao-hong; Zhang, Jia-li; Li, De-hua; Wang, Zhong-qiang; Fan, Jing-xian; He, Xian-yuan] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China; [Liu, Yan-ku; Jiang, Shang-ren] Chongqing Med Univ, Discipline Pediat, Chongqing, Peoples R China; [Li, Xin-ran; He, Xian-yuan] Chongqing Med Univ, Key Lab Metab & Metab Tradit Chinese Med Chongqing, Chongqing, Peoples R China
通信作者：He, XY (通讯作者)，Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China.
来源：HELIYON
ESI学科分类：
WOS号：WOS:001251058000001
JCR分区：Q1
影响因子：3.4
年份：2024
卷号：10
期号：5
开始页：
结束页：
文献类型：Article
关键词：Behavior; Estrogen receptor; Pathological morphology of brain tissue; Polygonatum cyrtonema; Postpartum depression
摘要：Background: Polygonatum cyrtonema Hua is a traditional Chinese medicinal food herb which can regulate the liver and Qi, nourish the heart and blood, moisten the lungs and nourish the kidneys with the potential to treat emotional diseases. However, few studies have explored the effects of Polygonatum cyrtonema Hua on postpartum depression. Therefore, we investigated whether processed Polygonatum cyrtonema Hua could improve postpartum depression in rat models by regulating monoamines and hormones. Methods: Female Sprague-Dawley rats were randomized into normal control (0.9%Nacl), Sham operation (0.9%Nacl), postpartum depression model (0.9%Nacl), fluoxetine (2.5 mg/kg Fluoxetine), low, medium and high dose of processed Polygonatum cyrtonema Hua (2.5 g/kg, 5 g/kg, 10 g/kg) groups. Rats in these groups received drug intervention, and then subjected to Open-field test and Forced swimming test. Brain tissues and serum samples were collected and used to quantify levels of monoamines, hypothalamic -pituitary -adrenal axis and serum Estradiol. The status of neuronal cells in hippocampus 1 region was examined through hematoxylin-eosin staining, whereas expression of estrogen receptor alpha and beta was detected by immunohistochemistry. Results: Rats in the model group showed decreased mobility time, the disorder of neuronal cells in hippocampus 1 area, and decreased concentration of 5-hydroxytryptamine and dopamine in brain tissue, norepinephrine and estradiol in serum as well as estrogen receptor alpha and beta expression. They also exhibited increased adrenocorticotropic hormone, corticosterone and corticotropin releasing hormone in serum. However, the treatment with processed Polygonatum cyrtonem Hua or fluoxetine reversed the above abnormalities. Conclusion: The H group showed significant improvement in postpartum depression in rats, and processed Polygonatum cyrtonema Hua can be used as a developing drug for the prevention or treatment of depression.
基金机构：Chongqing Science and Technology Commission [cstc2018jscx-msybX0288]; Key Project of Technology Innovation and Application Development of Traditional Chinese Medicine of Chongqing Science and Health Union [2021ZY013872]
基金资助正文：This work was funded by Chongqing Science and Technology Commission (project number: cstc2018jscx-msybX0288) and the Key Project of Technology Innovation and Application Development of Traditional Chinese Medicine of Chongqing Science and Health Union (project number: 2021ZY013872) .
