A Nature-Derived, Hetero-Structured, Pro-Healing Bioadhesive Patch for High-Performance Sealing of Wet Tissues

作者全名：Liu, Shilin; Xiang, Yangfan; Liu, Zekun; Li, Lan; Dang, Ruyi; Zhang, Huicong; Wei, Feng; Chen, Yuqin; Yang, Xiang; Mao, Mengjie; Zhang, Yu Shrike; Song, Jinlin; Zhang, Ximu

作者地址：[Liu, Shilin; Xiang, Yangfan; Liu, Zekun; Li, Lan; Dang, Ruyi; Zhang, Huicong; Chen, Yuqin; Yang, Xiang; Mao, Mengjie; Song, Jinlin; Zhang, Ximu] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Stomatol Hosp, Chongqing 401174, Peoples R China; [Wei, Feng] Peoples Hosp Kaizhou Dist, Chongqing 405499, Peoples R China; [Zhang, Yu Shrike] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA

通信作者：Song, JL; Zhang, XM (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Stomatol Hosp, Chongqing 401174, Peoples R China.; Zhang, YS (通讯作者)，Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA.

来源：ADVANCED MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001251970700001

JCR分区：Q1

影响因子：27.4

年份：2024

卷号：36

期号：25

开始页：　

结束页：　

文献类型：Article

关键词：Andrias davidianus; hydrophilic-hydrophobic; multilayered; pressure-trigger; wet adhesion

摘要：Tissue adhesives are promising alternatives to sutures and staples to achieve wound closure and hemostasis. However, they often do not work well on tissues that are soaked in blood or other biological fluids, and organs that are typically exposed to a variety of harsh environments such as different pH values, nonhomogeneous distortions, continuous expansions and contractions, or high pressures. In this study, a nature-derived multilayered hetero-bioadhesive patch (skin secretion of Andrias davidianus (SSAD)-Patch) based on hydrophilic/hydrophobic pro-healing bioadhesives derived from the SSAD is developed, which is designed to form pressure-triggered strong adhesion with wet tissues. The SSAD-Patch is successfully applied for the sealing and healing of tissue defects within 10 s in diverse extreme injury scenarios in vivo including rat stomach perforation, small intestine perforation, fetal membrane defect, porcine carotid artery incision, and lung lobe laceration. The findings reveal a promising new type of self-adhesive regenerative SSAD-Patch, which is potentially adaptable to broad applications (under different pH values and air or liquid pressures) in sutureless wound sealing and healing.

基金机构：National Natural Science Foundation of China; Science and Technology Research Project of Chongqing Education Commission [KJQN202200471]; CQMU Program for Youth Innovation in Future Medicine [W0075]; National Key R&D of Program of China [2022YFC2504200]; Outstanding Youth Fund of Chongqing Natural Science Foundation [CSTB2023NSCQ-JQX0006]; State Key Laboratory of Ultrasound in Medicine and Engineering [2022KFKT002]; Brigham Research Institute; [U22A20314]

基金资助正文：S.L., Y.X., Z.L., and L.L. contributed equally to this work. This work was financed by the National Natural Science Foundation of China (32070826), the National Natural Science Foundation of China (Grant No. U22A20314), Science and Technology Research Project of Chongqing Education Commission (KJQN202200471), CQMU Program for Youth Innovation in Future Medicine (W0075), National Key R&D of Program of China (2022YFC2504200), Outstanding Youth Fund of Chongqing Natural Science Foundation (CSTB2023NSCQ-JQX0006), and State Key Laboratory of Ultrasound in Medicine and Engineering (Grant No. 2022KFKT002). Y.S.Z. was not supported by any of these funds; instead, support by the Brigham Research Institute is acknowledged.