Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people
作者全名：Sun, Yuntao; Wang, Mengge; Sun, Qiuxia; Liu, Yan; Duan, Shuhan; Wang, Zhiyong; Zhou, Yunyu; Zhong, Jun; Huang, Yuguo; Huang, Xinyu; Yang, Qingxin; Li, Xiangping; Su, Haoran; Cai, Yan; Jiang, Xiucheng; Chen, Jing; Yan, Jiangwei; Nie, Shengjie; Hu, Liping; Yang, Junbao; Tang, Renkuan; Wang, Chuan-Chao; Liu, Chao; Deng, Xiaohui; Yun, Libing; He, Guanglin
作者地址：[Sun, Yuntao; Huang, Xinyu; Deng, Xiaohui; Yun, Libing] Sichuan Univ, West China Sch Basic Sci & Forens Med, Chengdu 610041, Sichuan, Peoples R China; [Sun, Yuntao; Wang, Mengge; Sun, Qiuxia; Liu, Yan; Duan, Shuhan; Wang, Zhiyong; Huang, Yuguo; Li, Xiangping; Su, Haoran; Jiang, Xiucheng; Chen, Jing; He, Guanglin] Sichuan Univ, West China Hosp, Inst Rare Dis, Chengdu 610000, Sichuan, Peoples R China; [Sun, Yuntao; Wang, Mengge; Yun, Libing; He, Guanglin] Sichuan Univ, Ctr Archaeol Sci, Chengdu 610000, Sichuan, Peoples R China; [Wang, Mengge] Sun Yat Sen Univ, Fac Forens Med, Zhongshan Sch Med, Guangzhou 510275, Guangdong, Peoples R China; [Wang, Mengge] Guangzhou Forens Sci Inst, Guangzhou 510055, Guangdong, Peoples R China; [Sun, Qiuxia; Tang, Renkuan] Chongqing Med Univ, Coll Basic Med, Dept Forens Med, Chongqing 400331, Peoples R China; [Liu, Yan; Su, Haoran; Cai, Yan; Jiang, Xiucheng; Yang, Junbao] North Sichuan Med Coll, Sch Clin Med Sci, Nanchong 637100, Sichuan, Peoples R China; [Duan, Shuhan; Zhong, Jun; Li, Xiangping; Su, Haoran; Cai, Yan; Jiang, Xiucheng] North Sichuan Med Coll, Sch Basic Med Sci, Nanchong 637100, Sichuan, Peoples R China; [Wang, Zhiyong; Yang, Qingxin; Li, Xiangping; Nie, Shengjie; Hu, Liping] Kunming Med Univ, Sch Forens Med, Kunming 650500, Yunnan, Peoples R China; [Zhou, Yunyu; Cai, Yan] North Sichuan Med Coll, Sch Stomatol, Nanchong 637100, Sichuan, Peoples R China; [Cai, Yan] North Sichuan Med Coll, Dept Med Lab, Nanchong 637007, Sichuan, Peoples R China; [Wang, Chuan-Chao] Xiamen Univ, Sch Life Sci, Xiamen 361005, Fujian, Peoples R China; [Chen, Jing; Yan, Jiangwei; Liu, Chao] Antidrug Technol Ctr Guangdong Prov, Guangzhou 510230, Guangdong, Peoples R China; [Chen, Jing; Yan, Jiangwei] Shanxi Med Univ, Sch Forens Med, Jinzhong 030600, Shanxi, Peoples R China
通信作者：Deng, XH; Yun, LB (通讯作者)，Sichuan Univ, West China Sch Basic Sci & Forens Med, Chengdu 610041, Sichuan, Peoples R China.; Wang, MG; He, GL (通讯作者)，Sichuan Univ, West China Hosp, Inst Rare Dis, Chengdu 610000, Sichuan, Peoples R China.; Wang, MG; Yun, LB; He, GL (通讯作者)，Sichuan Univ, Ctr Archaeol Sci, Chengdu 610000, Sichuan, Peoples R China.; Wang, MG (通讯作者)，Sun Yat Sen Univ, Fac Forens Med, Zhongshan Sch Med, Guangzhou 510275, Guangdong, Peoples R China.; Wang, MG (通讯作者)，Guangzhou Forens Sci Inst, Guangzhou 510055, Guangdong, Peoples R China.
来源：JOURNAL OF GENETICS AND GENOMICS
ESI学科分类：MOLECULAR BIOLOGY & GENETICS
WOS号：WOS:001252001600001
JCR分区：Q1
影响因子：6.6
年份：2024
卷号：51
期号：5
开始页：517
结束页：530
文献类型：Article
关键词：Tibeto-Burman people; Genetic profile; Natural selection; Genetic diversity; Biological adaptation
摘要：Tibeto-Burman (TB) people have endeavored to adapt to the hypoxic, cold, and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic period. However, the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people, as well as their interaction mechanism, remain unknown. Here, we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity, admixture history, and differentiated adaptative features of geographically different TB-speaking people. We identify genetic differentiation related to geography and language among TB-speaking people, consistent with their differentiated admixture process with incoming or indigenous ancestral source populations. A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin hypothesis. We finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish speakers. Adaptative signatures associated with the physical pigmentation ( EDAR and SLC24A5 ) and metabolism ( ALDH9A1 ) are identified in Loloish people, which differed from the high-altitude adaptative genetic architecture in Tibetan. TB-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research. Copyright (c) 2023, The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
基金机构：National Natural Science Foundation of China [82202078]; Center for Archaeological Science of Sichuan University [23SASA01]
基金资助正文：This work was supported by grants from the National Natural Science Foundation of China (82202078) and the Center for Archaeological Science of Sichuan University (23SASA01) . We thank Prof. Etienne Patin and Prof. Lluis Quintana-Murci from the Human Evolutionary Genetics Unit of the Institute Pasteur for sharing the high -coverage genomes of 317 individuals from the Pacific region. We thank Prof. Mark Stoneking, Prof. Dang Liu at Max Planck Insti- tute for Evolutionary Anthropology, and Prof. Wibhu Kutanan at Khon Kaen University for sharing genome-wide SNP data from Vietnam, Thailand, and Laos.
