Multifunctional nano-in-micro delivery systems for targeted therapy in fundus neovascularization diseases

作者全名：Liu, Xin; Huang, Keke; Zhang, Fuxiao; Huang, Ge; Wang, Lu; Wu, Guiyu; Ren, Hui; Yang, Guang; Lin, Zhiqing

作者地址：[Zhang, Fuxiao; Huang, Ge; Wang, Lu; Wu, Guiyu; Ren, Hui; Yang, Guang; Lin, Zhiqing] Chengdu Med Coll, Peoples Hosp Chengdu 2, Affiliated Hosp, Dept Ophthalmol, Chengdu 610031, Peoples R China; [Huang, Keke] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Dept Ophthalmol, Chengdu 610031, Peoples R China; [Liu, Xin] Chongqing Med Univ, Affiliated Hosp 3, Dept Ophthalmol, Chongqing 400010, Peoples R China

通信作者：Ren, H; Yang, G; Lin, ZQ (通讯作者)，Chengdu Med Coll, Peoples Hosp Chengdu 2, Affiliated Hosp, Dept Ophthalmol, Chengdu 610031, Peoples R China.

来源：JOURNAL OF NANOBIOTECHNOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001252056900002

JCR分区：Q1

影响因子：10.6

年份：2024

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Nano-in-micro (NIM) delivery system; Nanoparticles; Drug delivery; Fundus neovascular disease

摘要：Fundus neovascularization diseases are a series of blinding eye diseases that seriously impair vision worldwide. Currently, the means of treating these diseases in clinical practice are continuously evolving and have rapidly revolutionized treatment opinions. However, key issues such as inadequate treatment effectiveness, high rates of recurrence, and poor patient compliance still need to be urgently addressed. Multifunctional nanomedicine can specifically respond to both endogenous and exogenous microenvironments, effectively deliver drugs to specific targets and participate in activities such as biological imaging and the detection of small molecules. Nano-in-micro (NIM) delivery systems such as metal, metal oxide and up-conversion nanoparticles (NPs), quantum dots, and carbon materials, have shown certain advantages in overcoming the presence of physiological barriers within the eyeball and are widely used in the treatment of ophthalmic diseases. Few studies, however, have evaluated the efficacy of NIM delivery systems in treating fundus neovascular diseases (FNDs). The present study describes the main clinical treatment strategies and the adverse events associated with the treatment of FNDs with NIM delivery systems and summarizes the anatomical obstacles that must be overcome. In this review, we wish to highlight the principle of intraocular microenvironment normalization, aiming to provide a more rational approach for designing new NIM delivery systems to treat specific FNDs.

基金机构：Chengdu Medical Scientific Research Project; Youth Project of Sichuan Medical and Health Promotion Association [KY2023QN0014]; Chengdu Science and Technology Bureau's technology innovation research and development project; Third People's Hospital of Chengdu Scientific Research Project [2023PI23]; [2023028]

基金资助正文：Zhiqing Lin and Guang Yang thanks for the financial support from Chengdu Medical Scientific Research Project (Grant No. 2022282), Youth Project of Sichuan Medical and Health Promotion Association (Grant No. KY2023QN0014) and Chengdu Science and Technology Bureau's technology innovation research and development project (Grant No.2022-YF05-01861-SN). Keke Huang thanks for the financial support from Chengdu Medical Scientific Research Project (Grant No. 2023028) and The Third People's Hospital of Chengdu Scientific Research Project (Grant No. 2023PI23).