Association between serum lipid and all-cause mortality in asthmatic populations: a cohort study

作者全名：Wen, Jun; Zhuang, Rongjuan; He, Qingliu; Wei, Chengcheng; Giri, Mohan; Chi, Jing

作者地址：[Wen, Jun; Zhuang, Rongjuan; Giri, Mohan; Chi, Jing] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [He, Qingliu] Fujian Med Univ, Affiliated Hosp 2, Dept Urol, Quanzhou, Peoples R China; [He, Qingliu; Wei, Chengcheng] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Urol, Wuhan, Hubei, Peoples R China; [Wei, Chengcheng] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China

通信作者：Chi, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China.

来源：LIPIDS IN HEALTH AND DISEASE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001252372000003

JCR分区：Q2

影响因子：3.9

年份：2024

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Lipid; Low-density lipoprotein-cholesterol (LDL-C); Mortality; Asthma; National Health and Nutrition Examination Survey (NHANES); CoxBoost

摘要：Background Presently, the majority of investigations primarily evaluate the association between lipid profiles and asthma. However, few investigations explore the connection between lipids and mortality related to the disease. This study aims to explore the association of serum lipids with all-cause mortality within asthmatic adults. Methods The investigation included 3233 eligible patients with asthma from the NHANES (2011-2018). The potential associations were explored using three Cox proportional hazards models, restricted cubic splines (RCS), threshold effect models, and CoxBoost models. In addition, subgroup analyses were conducted to investigate these associations within distinct populations. Results After controlling all covariables, the Cox proportional hazards model proved a 17% decrease in the probability of death for each increased unit of low-density lipoprotein-cholesterol (LDL-C) (mmol/L). Yet, there was no association seen between blood high-density lipoprotein cholesterol (HDL-C), total cholesterol, or triglyceride and all-cause mortality in asthmatics. The application of RCS and threshold effect models verified an inverse and linear association of LDL-C with all-cause mortality. According to the results from the CoxBoost model, LDL-C exhibited the most substantial impact on the follow-up status of asthmatics among the serum lipids. Conclusion Our investigation concluded that in American asthmatic populations, LDL-C levels were inversely and linearly correlated with mortality. However, no independent relationship was found between triglycerides, total cholesterol, or HDL-C and mortality.

基金机构：Program for Youth Innovation in Future Medicine, Chongqing Medical University [2018-01]

基金资助正文：The CDC, responsible for supplying extensive health statistics for the country, has received official permission for NHANES methodology from the Research Ethics Review Board of the National Center for Health Statistics (NCHS). NHANES guaranteed participant rights by obtaining informed written consent from all individuals who participated in the study. The NHANES study protocol received approval from the Research Ethics Review Board of the NCHS (Ethical approval number: Protocol #2011-17, Protocol #2018-01).