Serum NLRP3: A potential marker for identifying high-risk coronary arterial aneurysm in children with Kawasaki disease

作者全名：Li, Mengling; Liu, Dong; Cheng, Zhenli; Zhou, Xue; Chen, Zhuo; Liu, Ruixi; Yi, Qijian

作者地址：[Li, Mengling; Liu, Dong; Cheng, Zhenli; Zhou, Xue; Chen, Zhuo; Liu, Ruixi; Yi, Qijian] Chongqing Med Univ, Int Sci & Technol Cooperat Base Dev & Crit Disord, Chongqing Key Lab Pediat Metab & Inflammatory Dis, Minist Educ,Key Lab Child Dev & Disorders,Natl Cli, Chongqing 400014, Peoples R China; [Li, Mengling] Sichuan Mianyang 404 Hosp, Dept Pediat, Mianyang 621000, Peoples R China; [Zhou, Xue; Liu, Ruixi; Yi, Qijian] Chongqing Med Univ, Dept Cardiovasc Med, Childrens Hosp, Chongqing 400014, Peoples R China

通信作者：Liu, RX; Yi, QJ (通讯作者)，Chongqing Med Univ, Int Sci & Technol Cooperat Base Dev & Crit Disord, Chongqing Key Lab Pediat Metab & Inflammatory Dis, Minist Educ,Key Lab Child Dev & Disorders,Natl Cli, Chongqing 400014, Peoples R China.

来源：CYTOKINE

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001252410200001

JCR分区：Q2

影响因子：3.7

年份：2024

卷号：180

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Kawasaki disease; NLRP3; Coronary arterial aneurysm; Coronary sequelae

摘要：Background: Kawasaki disease (KD) is a vasculitis of unknown etiology in children aged under 5 years. Coronary arterial aneurysm (CAA) is the major complication of KD. It is no longer though to be a self-limiting disease because its cardiovascular sequelae might persist into adulthood. NLRP3 is a key protein of the NLRP3 inflammasome that participates in sterile inflammatory disease. This study investigated the serum levels of NLRP3 in patients with KD at different stages to explore the relationships between serum NLRP3 and clinical parameters. Methods: A total of 247 children enrolled in this study. There were 123 patients in the acute stage of KD, and 93 healthy children made up the healthy control (HC) group. Among the acute KD patients, 52 had coronary arterial aneurysm (KD-CAA) and 71 did not (KD-NCAA). 36 patient samples were collected after IVIG and aspirin treatment. Additionally, 29 patients were in the cardiovascular sequelae stage. Enzyme-linked immunosorbent assay was used to measure serum NLRP3 levels in all subjects. Results: Serum NLRP3 was elevated in the KD group and was even higher in the KD-CAA subgroup than in the KD-NCAA subgroup of acute-stage patients. Serum NLRP3 declined when the patients were treated with IVIG and aspirin, but during the convalescent (coronary sequelae) stage, serum NLRP3 re-increased. Serum NLRP3 was higher in the >= 6-mm-coronary-arterial-diameter group than that the < 6-mm-diameter group. The ROC curve of serum NLRP3 indicated its utility in the prediction of both KD and KD-CAA. Conclusions: NLRP3 may be involved in the development of KD and CAA in children with KD. Targeting NLRP3 might mitigate CAA, thereby reducing the risk of cardiovascular events in adulthood.

基金机构：General Program of Natural Science Funding of Chongqing [cstc2021jcyj-msxmX0419]

基金资助正文：We appreciate the recruited children for their kindness to support the development of medicine. This study was supported by The General Program of Natural Science Funding of Chongqing (Grant number. cstc2021jcyj-msxmX0419)