Chronic active Epstein-Barr virus infection with reinfection of SARS-CoV-2: a case report

作者全名：Wu, Hongmei; Liu, Li; Qu, Jialin; Wang, Chunrui; Shi, Xiaofeng; Lei, Yu

作者地址：[Wu, Hongmei; Qu, Jialin; Wang, Chunrui; Shi, Xiaofeng; Lei, Yu] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minis, 288 Tianwen Rd, Chongqing 400060, Peoples R China; [Liu, Li] Chongqing Med Univ, Affiliated Hosp 2, Dept Pathol, 288 Tianwen Rd, Chongqing 400060, Peoples R China

通信作者：Lei, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minis, 288 Tianwen Rd, Chongqing 400060, Peoples R China.

来源：VIROLOGY JOURNAL

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001252535300001

JCR分区：Q2

影响因子：4

年份：2024

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：SARS-CoV-2; Chronic active Epstein Barr virus (CAEBV); Co-infection; Reinfection

摘要：We describe the case of a 57-year-old male with jaundice, abdominal distension and fatigue. He was diagnosed as chronic active Epstein-Barr virus infection (CAEBV) due to intermittent elevated liver enzymes, hepatosplenomegaly and pancytopenia, with persistent positive of EBV biomarkers in blood and also positive in liver tissue. The patient was reinfected by SARS-CoV-2 within 2 months companied with CAEBV. The patient's second infection with SARS-CoV-2 led to the aggravated liver dysfunction with pneumonia and re-admission. After receiving symptomatic treatment, the patient showed significantly improvement of symptoms with partially restoration of liver function. After discharge, the patient's health status continued to deteriorate and eventually died. The instances of SARS-CoV-2 co-infection with the original chronic virus are not uncommon, but the exact mechanism of EBV and SARS-CoV-2 coinfection and the relationship between them are still unclear. Since co-infection of SARS-CoV-2 with original chronic virus might affect each other and lead disease aggravated and complicated, it is necessary to differentiate in the diagnosis of disease and it is important to be aware of the re-infection signs of SARS-CoV-2 in people with chronic virus infection diseases, as well as the risk of co-infection of SARS-CoV-2 with other viruses.

基金机构：National Natural Science Foundation of China [31000397]; Senior Medical Talents Program of Chongqing for Young and Middle-aged, China [2020]

基金资助正文：This work was supported by the National Natural Science Foundation of China [grant numbers 31000397 to Yu Lei], Senior Medical Talents Program of Chongqing for Young and Middle-aged, China [grant numbers 2020 to Yu Lei].