Rapid screening and sensing of stearoyl-CoA desaturase 1 (SCD1) inhibitors from ginger and their efficacy in ameliorating non-alcoholic fatty liver disease

作者全名："Zeng, Xin; Wang, Shang; Peng, Ze; Wang, Meng; Zhao, Kui; Xu, Ben Bin; Yin, Xiongwei; Ibrahim, Mohamed M.; Mersal, Gaber A. M.; El-Bahy, Zeinhom M.; Guo, Zhanhu; Xiang, Wei; Wang, Jianwei"

作者地址："[Zeng, Xin; Wang, Shang; Peng, Ze; Wang, Meng; Wang, Jianwei] Chongqing Med Univ, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 400016, Peoples R China; [Zeng, Xin; Xiang, Wei; Wang, Jianwei] Chongqing Coll Tradit Chinese Med, Chongqing 402760, Peoples R China; [Yin, Xiongwei] Univ Leuven, KU Leuven, Dept Pharmaceut & Pharmacol Sci, Pharmaceut Anal, Herestr 49,O&N2,PB 923, B-3000 Leuven, Belgium; [Zhao, Kui] Southwest Forestry Univ, Coll Mat Sci & Chem Engn, Kunming 650224, Peoples R China; [Xu, Ben Bin; Guo, Zhanhu] Northumbria Univ, Dept Mech & Civil Engn, Newcastle Upon Tyne NE1 8ST, England; [Ibrahim, Mohamed M.; Mersal, Gaber A. M.] Taif Univ, Coll Sci, Dept Chem, POB 11099, Taif 21944, Saudi Arabia; [El-Bahy, Zeinhom M.] Al Azhar Univ, Fac Sci, Dept Chem, Cairo 11884, Egypt"

通信作者："Wang, JW (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 400016, Peoples R China.; Xiang, W; Wang, JW (通讯作者)，Chongqing Coll Tradit Chinese Med, Chongqing 402760, Peoples R China.; Guo, ZH (通讯作者)，Northumbria Univ, Dept Mech & Civil Engn, Newcastle Upon Tyne NE1 8ST, England."

来源：JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001252658100002

JCR分区：Q2

影响因子：3.4

年份：2024

卷号：18

期号：8

开始页：6843

结束页：6857

文献类型：Article

关键词：Ginger; Magnetite; Inhibitor; Fatty liver

摘要："Non-alcoholic fatty liver disease is a prevalent chronic metabolic condition, for which no approved medications are available. As a condiment and traditional Chinese medicine, ginger can be useful in reducing the symptoms of non-alcoholic fatty liver disease. Although its active ingredients and mechanisms of action are unknown, there is a lack of research on them. The purpose of this study is to prepare magnetite (Fe3O4)@Stearoyl-CoA desaturase 1 (SCD1) materials and analyze them using ultra-high performance liquid-chromatography-mass spectrometry (UPLC-MS) for rapid screening of potential inhibitors of SCD1 in ginger. Based on this analysis, it has been shown that the primary components in ginger that bind SCD1 directly are gingerols, with 10-gingerol having a greater affinity for binding to SCD1 than 8-gingerol and 6-gingerol. Moreover, further studies indicated that free fatty acids (FFA)-induced lipid accumulation is improved by this class of compounds in normal human hepatocytes (THLE-3), with 10-gingerol being the most effective compound. This study provides a new insight into the mechanism, by which ginger contributes to the improvement of non-alcoholic fatty liver disease (NAFLD) and provide support for the effective use of 10-gingerol for the treatment of NAFLD."

基金机构："Taif University, Saudi Arabia [TU-DSPP-2024-21]"

基金资助正文："The authors extend their appreciation to Taif University, Saudi Arabia for supporting this work through project number (TU-DSPP-2024-21)."