Case report: Sacral neuromodulation for neurogenic lower urinary tract dysfunction in patient with neuronal intranuclear inclusion disease

作者全名：Jin, Xiaosong; Tang, Haibin; Yuan, Heng; Chen, Gang

作者地址：[Jin, Xiaosong; Tang, Haibin; Yuan, Heng; Chen, Gang] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China

通信作者：Chen, G (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China.

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001253064000001

JCR分区：Q1

影响因子：3.4

年份：2024

卷号：10

期号：12

开始页：　

结束页：　

文献类型：Article

关键词：Neuronal intranuclear inclusion disease; Sacral neuromodulation; Neurogenic lower urinary tract dysfunction; Lower urinary tract symptoms; Case report

摘要：Neuronal intranuclear inclusion disease is an uncommon neurodegenerative disorder. The diagnosis of this condition has become more definitive based on current research. However, treatment options remain limited. Neurogenic lower urinary tract dysfunction is one of the prevalent and significant complications, which is the result of its multi-system effects. Here, we present the case of a 48-year-old man diagnosed with neuronal intranuclear inclusion disease based on existing evidence and was complicated by neurogenic lower urinary tract dysfunction. Despite undergoing some medical treatments, his lower urinary tract symptoms, including urinary incontinence, incomplete or intermittent voiding, etc, continued to worsen while upper urinary tract injury developed. Based on careful consideration of the patient's condition and the available findings, we performed an unprecedented sacral neuromodulation on him. Implementation of sacral neuromodulation led to significant improvement in his urination function and alleviate kidney function damage. Our case suggests a potential therapeutic role for sacral neuromodulation in the treatment of neurogenic lower urinary tract dysfunction associated with neuronal intranuclear inclusion disease. Additional research is required to determine the effectiveness of sacral neuromodulation in managing neurogenic lower urinary tract dysfunction caused by various etiologies.

基金机构：Senior Medical Talents Program of Chongqing for Young and Middle-aged Science - Chongqing Municipal Health Commission [2022GDRC014]; Smart Medicine Project of Chongqing Medical University in 2021 [ZHYX202124]

基金资助正文：The authors declare that this study received funding from the Senior Medical Talents Program of Chongqing for Young and Middle-aged Science supported by Chongqing Municipal Health Commission (number 2022GDRC014) and Smart Medicine Project of Chongqing Medical University in 2021 (project No. ZHYX202124) . The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.