The interaction between oral microbiota and gut microbiota in atherosclerosis

作者全名：Li, Xinsi; Li, Qian; Wang, Li; Ding, Huifen; Wang, Yizhong; Liu, Yunfei; Gong, Ting

作者地址：[Li, Xinsi; Li, Qian; Wang, Li; Ding, Huifen; Liu, Yunfei; Gong, Ting] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Li, Xinsi; Li, Qian; Wang, Li; Ding, Huifen; Liu, Yunfei; Gong, Ting] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Wang, Li; Liu, Yunfei; Gong, Ting] Chongqing Med Univ, Dept Implantol, Stomatol Hosp, Chongqing, Peoples R China; [Ding, Huifen] Chongqing Med Univ, Dept Prosthodont, Stomatol Hosp, Chongqing, Peoples R China; [Wang, Yizhong] Zhejiang Charioteer Pharmaceut Co LTD, Dept Res & Dev, Taizhou, Peoples R China

通信作者：Liu, YF; Gong, T (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China.; Liu, YF; Gong, T (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China.; Liu, YF; Gong, T (通讯作者)，Chongqing Med Univ, Dept Implantol, Stomatol Hosp, Chongqing, Peoples R China.

来源：FRONTIERS IN CARDIOVASCULAR MEDICINE

ESI学科分类：　

WOS号：WOS:001254091400001

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：atherosclerosis; oral microbiota; gut microbiota; interaction; NO; LPS

摘要：Atherosclerosis (AS) is a complex disease caused by multiple pathological factors threatening human health-the pathogenesis is yet to be fully elucidated. In recent years, studies have exhibited that the onset of AS is closely involved with oral and gut microbiota, which may initiate or worsen atherosclerotic processes through several mechanisms. As for how the two microbiomes affect AS, existing mechanisms include invading plaque, producing active metabolites, releasing lipopolysaccharide (LPS), and inducing elevated levels of inflammatory mediators. Considering the possible profound connection between oral and gut microbiota, the effect of the interaction between the two microbiomes on the initiation and progression of AS has been investigated. Findings are oral microbiota can lead to gut dysbiosis, and exacerbate intestinal inflammation. Nevertheless, relevant research is not commendably refined and a concrete review is needed. Hence, in this review, we summarize the most recent mechanisms of the oral microbiota and gut microbiota on AS, illustrate an overview of the current clinical and epidemiological evidence to support the bidirectional connection between the two microbiomes and AS.

基金机构：Natural Science Foundation of Chongqing, China [cstc2021jcyjbshX0176]; National Natural Science Foundation of China [81900980]

基金资助正文：This research was funded by Natural Science Foundation of Chongqing, China, grant number cstc2021jcyjbshX0176 and National Natural Science Foundation of China, grant number 81900980