Glucose-6-phosphate dehydrogenase alleviates epileptic seizures by repressing reactive oxygen species production to promote signal transducer and activator of transcription 1-mediated N-methyl-d-aspartic acid receptors inhibition
作者全名：Hu, Liqin; Liu, Yan; Yuan, Ziwei; Guo, Haokun; Duan, Ran; Ke, Pingyang; Meng, Yuan; Tian, Xin; Xiao, Fei
作者地址：[Hu, Liqin; Liu, Yan; Yuan, Ziwei; Guo, Haokun; Duan, Ran; Ke, Pingyang; Meng, Yuan; Tian, Xin; Xiao, Fei] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing Key Lab Major Neurol & Mental Disorders, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Tian, Xin; Xiao, Fei] Chongqing Med Univ, Key Lab Major Brain Dis & Aging Res, Minist Educ, Chongqing 400016, Peoples R China
通信作者：Tian, X; Xiao, F (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing Key Lab Major Neurol & Mental Disorders, 1 Youyi Rd, Chongqing 400016, Peoples R China.
来源：REDOX BIOLOGY
ESI学科分类：BIOLOGY & BIOCHEMISTRY
WOS号：WOS:001254843700001
JCR分区：Q1
影响因子：10.7
年份：2024
卷号：74
期号：
开始页：
结束页：
文献类型：Article
关键词：Epilepsy; G6PD; Reactive oxygen species; STAT1
摘要：The pathogenesis of epilepsy remains unclear; however, a prevailing hypothesis suggests that the primary underlying cause is an imbalance between neuronal excitability and inhibition. Glucose -6 -phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway, which is primarily involved in deoxynucleic acid synthesis and antioxidant defense mechanisms and exhibits increased expression during the chronic phase of epilepsy, predominantly colocalizing with neurons. G6PD overexpression significantly reduces the frequency and duration of spontaneous recurrent seizures. Furthermore, G6PD overexpression enhances signal transducer and activator of transcription 1 (STAT1) expression, thus influencing N-methyl- D -aspartic acid receptors expression, and subsequently affecting seizure activity. Importantly, the regulation of STAT1 by G6PD appears to be mediated primarily through reactive oxygen species signaling pathways. Collectively, our findings highlight the pivotal role of G6PD in modulating epileptogenesis, and suggest its potential as a therapeutic target for epilepsy.
基金机构：Foundation of Chongqing [CSTB2022NSCQ-MSX0747, CSTB2023NSCQ-JQX0035, CSTB2022NSCQ-LZX0038, cstc2021ycjh-bgzxm0035]; Future Medical Youth Innovation Team of Chongqing Medical University [W0043]; Young and Middle-aged Medical Excel-lence Team Program of Chongqing [2022]; Chongqing Chief Expert Studio program [2022]; Key Basic Research Project of the Discipline Climbing Plan of the First Affiliated Hospital of Chongqing Medical University [cyyy-xkdfjh-jcyj-202306]; China Postdoctoral Science Foundation [2023M730443]; Joint Project of Chongqing Health Commission and Science and Technology Bureau [2023QNXM009]; Science and Technology Research Program of Chongqing Education Commission [KJQN202200435]
基金资助正文：This work was supported by grants from the National Natural Science Foundation of China (82271496, 82001378) , National Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0747, CSTB2023NSCQ-JQX0035, CSTB2022NSCQ-LZX0038, cstc2021ycjh-bgzxm0035) , Future Medical Youth Innovation Team of Chongqing Medical University (W0043) , Young and Middle-aged Medical Excel-lence Team Program of Chongqing (2022) , and Chongqing Chief Expert Studio program (2022) , Key Basic Research Project of the Discipline Climbing Plan of the First Affiliated Hospital of Chongqing Medical University (cyyy-xkdfjh-jcyj-202306) , China Postdoctoral Science Foundation (2023M730443) , the Joint Project of Chongqing Health Commission and Science and Technology Bureau (2023QNXM009) , Science and Technology Research Program of Chongqing Education Commission (KJQN202200435) .r Foundation of Chongqing (CSTB2022NSCQ-MSX0747, CSTB2023NSCQ-JQX0035, CSTB2022NSCQ-LZX0038, cstc2021ycjh-bgzxm0035) , Future Medical Youth Innovation Team of Chongqing Medical University (W0043) , Young and Middle-aged Medical Excel-lence Team Program of Chongqing (2022) , and Chongqing Chief Expert Studio program (2022) , Key Basic Research Project of the Discipline Climbing Plan of the First Affiliated Hospital of Chongqing Medical University (cyyy-xkdfjh-jcyj-202306) , China Postdoctoral Science Foundation (2023M730443) , the Joint Project of Chongqing Health Commission and Science and Technology Bureau (2023QNXM009) , Science and Technology Research Program of Chongqing Education Commission (KJQN202200435) .
