Blood urea nitrogen to creatinine ratio is associated with in-hospital mortality in critically ill patients with venous thromboembolism: a retrospective cohort study

作者全名：Puri, Anju; Giri, Mohan; Huang, Huanhuan; Zhao, Qinghua

作者地址：[Puri, Anju; Huang, Huanhuan; Zhao, Qinghua] Chongqing Med Univ, Affiliated Hosp 1, Dept Nursing, Chongqing, Peoples R China; [Giri, Mohan] Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Chongqing, Peoples R China

通信作者：Zhao, QH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Nursing, Chongqing, Peoples R China.

来源：FRONTIERS IN CARDIOVASCULAR MEDICINE

ESI学科分类：　

WOS号：WOS:001255142400001

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：venous thromboembolism; blood urea nitrogen to creatinine ratio; intensive care unit; in-hospital mortality; critically ill

摘要：Background: The relationship between the blood urea nitrogen to creatinine ratio (BCR) and the risk of in-hospital mortality among intensive care unit (ICU) patients diagnosed with venous thromboembolism (VTE) remains unclear. This study aimed to assess the relationship between BCR upon admission to the ICU and in-hospital mortality in critically ill patients with VTE. Methods: This retrospective cohort study included patients diagnosed with VTE from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The primary endpoint was in-hospital mortality. Univariate and multivariate logistic regression analyses were conducted to evaluate the prognostic significance of the BCR. Receiver operating characteristic (ROC) curve analysis was utilized to determine the optimal cut-off value of BCR. Additionally, survival analysis using a Kaplan-Meier curve was performed. Results: A total of 2,560 patients were included, with a median age of 64.5 years, and 55.5% were male. Overall, the in-hospital mortality rate was 14.6%. The optimal cut-off value of the BCR for predicting in-hospital mortality in critically ill VTE patients was 26.84. The rate of in-hospital mortality among patients categorized in the high BCR group was significantly higher compared to those in the low BCR group (22.6% vs. 12.2%, P < 0.001). The multivariable logistic regression analysis results indicated that, even after accounting for potential confounding factors, patients with elevated BCR demonstrated a notably increased in-hospital mortality rate compared to those with lower BCR levels (all P < 0.05), regardless of the model used. Patients in the high BCR group exhibited a 77.77% higher risk of in-hospital mortality than those in the low BCR group [hazard ratio (HR): 1.7777; 95% CI: 1.4016-2.2547]. Conclusion: An elevated BCR level was independently linked with an increased risk of in-hospital mortality among critically ill patients diagnosed with VTE. Given its widespread availability and ease of measurement, BCR could be a valuable tool for risk stratification and prognostic prediction in VTE patients.

基金机构：Chongqing Science and Technology Bureau [CSTC2021jscx-gksb-N0021]

基金资助正文：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Chongqing Science and Technology Bureau (Grant number: CSTC2021jscx-gksb-N0021).