Hyperuricemia and gout enhanced the risk of long-term mortality in hypertension: insights from the National Health and Nutrition Examination Survey 2007-2018

作者全名："Che, Jinhang; Tong, Jin; Kuang, Xue; Zheng, Caiyin; He, Na; Liu, Zengzhang"

作者地址："[Che, Jinhang; Kuang, Xue; Zheng, Caiyin; He, Na; Liu, Zengzhang] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China; [Tong, Jin] Chongqing Med Univ, Affiliated Hosp 2, Dept Respirol, Chongqing, Peoples R China"

通信作者："Liu, ZZ (通讯作者)，288 Tianwen Ave, Chongqing 401336, Peoples R China."

来源：JOURNAL OF HYPERTENSION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001256010700010

JCR分区：Q1

影响因子：4.9

年份：2024

卷号：42

期号：8

开始页：1390

结束页：1398

文献类型：Article

关键词：gout; hypertension; hyperuricemia; mortality; serum uric acid

摘要："Background:Asymptomatic hyperuricemia (HUA) and normouricemic gout are common in clinic but recommendations for them in hypertension management are absent. The present study aims to simultaneously evaluate the effect of HUA and gout on long-term mortality in hypertension.Methods:Individuals from 2007-2018 National Health and Nutrition Examination Survey were enrolled. Hazard ratios and 95% confidence intervals (CIs) were calculated with the aid of the Cox proportional-hazards model. The restricted cubic spline (RCS) analysis was made to show the dose-response relationship between uric acid and mortality. All-cause mortality and cardiovascular mortality were compared using the Kaplan-Meier curve with a log-rank test.Results:Thirty thousand eight hundred and nineteen eligible individuals were included, of which 5841 suffered from HUA and 1476 suffered from gout. During a median follow-up of 7.25 (95% CI 7.18-7.32) years, 2924 (6.8%) patients died, including 722 (1.6%) cases of cardiovascular death. Hypertensive patients with HUA and gout showed 1.34 and 1.29 times higher all-cause mortality compared with those without HUA or gout. For hypertensive patients without gout, HUA was significantly associated with higher risk of all-cause [1.27 (1.13, 1.43)] and cardiovascular [1.80 (1.44, 2.24)] mortality compared with normouricemia. However, for hypertensive patients without HUA, gout was associated with a higher mortality but not statistically significant. A J-shaped relationship was found between serum uric acid and mortality.Conclusion:HUA and gout are additive risk factors for all-cause and cardiovascular mortality in hypertension. Furthermore, asymptomatic HUA is significantly associated with poor long-term prognosis but normouricemic gout is not."

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