Toll-like receptor signaling pathway involved in pathogenesis of thromboangiitis obliterans through activating of NF-κB

作者全名："Guo, Facai; Bi, Yan; Yin, Jiangyan; Guo, Yi"

作者地址："[Guo, Facai] Lanzhou Univ, Dept Vasc Surg, Hosp 2, Lanzhou, Gansu, Peoples R China; [Bi, Yan] Lanzhou Univ, Dept Lab Med Ctr, Hosp 2, Lanzhou, Gansu, Peoples R China; [Yin, Jiangyan] Chongqing Med Univ, Affiliated Hosp 1, Dept Ultrasound, Chongqing, Peoples R China; [Guo, Yi] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Gen Surg, Chongqing, Peoples R China"

通信作者："Guo, Y (通讯作者)，Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Gen Surg, Chongqing, Peoples R China."

来源：CLINICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001256184600001

JCR分区：Q2

影响因子：2.7

年份：2024

卷号：79

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Thromboangiitis obliterans; TLR signaling pathway; MyD88; TRIF; NF-kappa B; Pathogenic mechanism

摘要："Objectives: The pathogenic mechanisms of Thromboangiitis Obliterans (TAO) are not entirely known and autoimmune in flammation plays a vital role in the initiation and continuance of TAO activity. The authors investigated in this study the role of the TLR signaling pathway in the pathogenesis of TAO. Methods: First, the authors detected the expressions of MyD88, TRIF and NF -kappa B in vascular walls of 46 patients with TAO and 32 patients with trauma and osteosarcoma by western blot assay. Second, the authors detected the cellular localization of MyD88, TRIF and NF -KB in vascular walls of patients with TAO by immuno fluorescent assay. Results: The protein expressions of MyD88, TRIF and NF -kappa B were much higher in vascular walls of TAO patients ( p < 0.05). Higher expressions of MyD88 and NF -kappa B were detected both on vascular endothelial and vascular smooth muscle cells of TAO patients. However, higher expression of TRIF was just detected on vascular smooth muscle cells of TAO patients. Conclusions: These dates suggest that the TLR signaling pathway might play an important role in the pathogenesis of TAO, it might induce vasospasm, vasculitis and thrombogenesis to lead to the pathogenesis and progression of TAO."

基金机构：Natural Science Foundation of Gansu Province [2020-0405-JCC-1467]; Natural Science Foundation of Lanzhou [20JR10RA742]; Cuiying Science and Technology Innovation project of Lanzhou University second hospital [CYXZ2019-25]

基金资助正文："This work was supported by the Natural Science Foundation of Gansu Province (2020-0405-JCC-1467), Natural Science Foundation of Lanzhou (20JR10RA742), and ""Cuiying Science and Technology Innovation"" project of Lanzhou University second hospital (CYXZ2019-25)."