Advances in noncoding RNA in children allergic rhinitis

作者全名："Li, Shuman; Cui, Hongtao; Lu, Huina; Zheng, Shan; Yuan, Chao"

作者地址："[Li, Shuman] Chongqing Med Univ, Chongqing, Peoples R China; [Cui, Hongtao; Lu, Huina; Zheng, Shan; Yuan, Chao] Chongqing Tradit Chinese Med Hosp, Dept Pediat, 6 Panxi Qizhi Rd, Chongqing 400021, Peoples R China"

通信作者："Yuan, C (通讯作者)，Chongqing Tradit Chinese Med Hosp, Dept Pediat, 6 Panxi Qizhi Rd, Chongqing 400021, Peoples R China."

来源：INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001258128400001

JCR分区：Q1

影响因子：6.4

年份：2024

卷号：14

期号：8

开始页：1350

结束页：1362

文献类型：Review

关键词：biomarkers; children allergic rhinitis; immunomodulatory; noncoding RNA

摘要："Background: A chronic condition that significantly reduces a child's quality of life is allergic rhinitis (AR). The environment and allergens that the body is regularly exposed to can cause inflammatory and immunological reactions, which can change the expression of certain genes Epigenetic changes are closely linked to the onset and severity of allergy disorders according to mounting amounts of data. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases. Methods: Articles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized. Results: Recent findings indicate that various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks. Conclusion: This article demonstrates the significance and progress of ncRNAs in children's AR. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore."

基金机构："Chongqing Scientific Research Institutions Performance Incentive and Guidance Project (College Level) [jxyn2021-1-6]; Postdoctoral Special Foundation Grant by Chongqing Bureau of Human Resources and Social Security [2022CQBSHTB1029]; Natural Science Foundation of Chongqing, China [cstc2021jcyj-msxmX0505]"

基金资助正文："Chongqing Scientific Research Institutions Performance Incentive and Guidance Project (College Level), Grant/Award Number: jxyn2021-1-6; Postdoctoral Special Foundation Grant by Chongqing Bureau of Human Resources and Social Security, Grant/Award Number: 2022CQBSHTB1029; Natural Science Foundation of Chongqing, Grant/Award Number: cstc2021jcyj-msxmX0505"