CD177 on neutrophils engages stress-related behavioral changes in male mice

作者全名："Meng, Ling; Zhou, Mi; Wang, Yunpeng; Pan, Yiming; Chen, Zheng; Wu, Bin; Zhao, Yan"

作者地址："[Meng, Ling; Zhou, Mi; Zhao, Yan] Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China; [Wang, Yunpeng] Chongqing Med Univ, Childrens Hosp, Pediat Res Inst, Natl Clin Res Ctr Child Hlth & Disorders,Minist Ed, Chongqing, Peoples R China; [Pan, Yiming] Chongqing Med Univ, Sch Basic Med Sci, Dept Cell Biol & Genet, Lab Dev Biol, Chongqing, Peoples R China; [Chen, Zheng] Chongqing Med Univ, Affiliated Hosp 1, Dept Vasc Surg, Chongqing, Peoples R China; [Wu, Bin] Chongqing Med Univ, Childrens Hosp, Pediat Res Inst, Growth Dev & Mental Hlth Children & Adolescence Ct, Chongqing, Peoples R China"

通信作者："Zhao, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Resp Med, Chongqing, Peoples R China.; Wu, B (通讯作者)，Chongqing Med Univ, Childrens Hosp, Pediat Res Inst, Growth Dev & Mental Hlth Children & Adolescence Ct, Chongqing, Peoples R China."

来源：BRAIN BEHAVIOR AND IMMUNITY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001259510400001

JCR分区：Q1

影响因子：15.1

年份：2024

卷号：120

期号：　

开始页：403

结束页：412

文献类型：Article

关键词：CD177; Psychological stress; Innate immunity; Neutrophil; Behavior

摘要："Persistent psychological stress can affect immune homeostasis and is a key factor in the development of depression. Many efforts are focused on the identifcation of pathways that link the immune system and mood disorders. Here, we found that psychological stress caused an increase in the frequency of brain-associated neutrophils and the level of neutrophil-specific antigen CD177 on peripheral neutrophils in male mice. Upregulated levels of blood CD177 are associated with depression in humans. Neutrophil depletion or Cd177 deficiency protected mice from stress-induced behavioral deficits. Importantly, adoptive transfer of CD177 + neutrophils from stressed mice increased the frequency of brain-associated leukocytes, including neutrophils, and caused behavioral defects in naive mice. These effects may be related to the endothelial adhesion advantage of CD177 + neutrophils and the interference of serine protease on endothelial junction. Our findings suggest a critical link between circulating CD177 + neutrophils and psychological stress -driven behavioral disorder."

基金机构：National Natural Science Foundation of China [82100087]; China Postdoctoral Science Foundation [2021M683761]; Chongqing Municipal Science and Technology Bureau [cstc2020jcyj-msxmX0078]; Second Affiliated Hospital of Chongqing Medical University

基金资助正文："This work was supported by the National Natural Science Foundation of China (82100087) (Y.Z.) , the China Postdoctoral Science Foundation (2021M683761) (Y.Z.) , the Chongqing Municipal Science and Technology Bureau (cstc2020jcyj-msxmX0078) (Y.Z.) , and the ""Kuanren Yingcai. Excellent Youth Talents"" project of the Second Affiliated Hospital of Chongqing Medical University (Y.Z.) ."