Stent-to-vessel diameter ratio is associated with in-stent stenosis after flow-diversion treatment of intracranial aneurysms

作者全名："Huang, Chi; Feng, Xin; Tong, Xin; Wen, Zhuohua; Zhu, Yajun; Xu, Anqi; Huang, Mengshi; Ma, Gengwu; Hu, Yuqi; Shi, Hongyu; Guo, Zongduo; Liu, Aihua; Duan, Chuanzhi"

作者地址："[Huang, Chi; Feng, Xin; Wen, Zhuohua; Xu, Anqi; Huang, Mengshi; Ma, Gengwu; Hu, Yuqi; Shi, Hongyu; Duan, Chuanzhi] Southern Med Univ, Dept Cerebrovasc Surg, Engn Technol Res Ctr Educ Minist China Diag & Trea, Zhujiang Hosp,Neurosurg Ctr, Guangzhou, Peoples R China; [Tong, Xin; Liu, Aihua] Beijing Neurosurg Inst, Neurointervent Ctr, Beijing, Peoples R China; [Zhu, Yajun; Guo, Zongduo] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China"

通信作者："Duan, CZ (通讯作者)，Zhujiang Hosp, Guangzhou, Guangdong, Peoples R China."

来源：JOURNAL OF STROKE & CEREBROVASCULAR DISEASES

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001262494500001

JCR分区：Q2

影响因子：2.5

年份：2024

卷号：33

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：Intracranial aneurysm; Flow diverter devices; In-stent stenosis; Cerebrovascular disease; stent size match; stent-to-vessel diameter ratio

摘要："Background and purpose: Flow -diversion treatment for intracranial aneurysms has been associated with the development of in-stent stenosis (ISS) for unclear reasons. We assess whether the size of the stent relative to that of the vessel (the stent-to-vessel diameter ratio, or SVR) may be predictive of the development of ISS after treatment with flow diverters. Methods: We retrospectively reviewed patients with unruptured intracranial aneurysms who underwent flowdiversion treatment using either the Pipeline or Tubridge embolization device from September 2018 to September 2022. The relationship between SVR and ISS was analyzed. Multiple logistic regression models were used to determine the significant predictors. Results: A total of 458 patients with 481 aneurysms were included. In a mean angiographic follow-up of 10.73 +/- 3.97 months, ISS was detected in 68 cases (14.1 %). After adjusting for candidate variables, a higher distal SVR (DSVR) was associated with an increased risk of ISS (adjusted odds ratio [aOR] = 3.420, 95 % confidence interval [CI] = 1.182 - 9.889, p = 0.023). We conducted a subgroup analysis of the two different flow diverters to assess the effects of their individual characteristics. Our results showed a significant association between the DSVR and the incidence of ISS in both the Pipeline (aOR = 4.033, 95 % CI = 1.156-14.072, p = 0.029) and Tubridge groups (aOR = 11.981, 95 % CI =1.005-142.774, p = 0.049). Conclusion: A higher DSVR was associated with an increased risk of ISS. This may help neurointerventionalists select an appropriate stent size when conducting flow -diversion treatment for intracranial aneurysms."

基金机构："Foundation of National Heath Commission Capacity Building and Continuing Education Center [GWJJ2022100102]; National Natural Science Foundation of China [82171290, 82201427, 82071332]"

基金资助正文：This current study was supported by the Foundation of National Heath Commission Capacity Building and Continuing Education Center (No. GWJJ2022100102) and the National Natural Science Foundation of China (Nos. 82171290; 82201427; and 82071332) .