"In vitro and in vivo studies of a biodegradable Zn-4Ag-0.1Sc alloy with high strength-elongation product, cytocompatibility, osteogenic differentiation, and anti-infection properties for guided bone-regeneration membrane applications"

作者全名："Tong, Xian; Shen, Xinkun; Lin, Zhiqiang; Lu, Lei; Munir, Khurram; Zhou, Runqi; Zhu, Li; Li, Yuncang; Ma, Jianfeng; Wen, Cuie; Lin, Jixing"

作者地址："[Tong, Xian; Lin, Zhiqiang; Lu, Lei; Zhu, Li; Ma, Jianfeng; Lin, Jixing] Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325027, Peoples R China; [Tong, Xian] Xiangtan Univ, Sch Mat Sci & Engn, Xiangtan 411105, Peoples R China; [Shen, Xinkun] Wenzhou Med Univ, Affiliated Hosp 3, Ruian Peoples Hosp, Dept Orthopaed, Wenzhou 325016, Peoples R China; [Munir, Khurram; Li, Yuncang; Wen, Cuie] RMIT Univ, Ctr Addit Mfg, Sch Engn, Melbourne, Vic 3001, Australia; [Zhou, Runqi] Chongqing Med Univ, Higher Educ & Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401174, Peoples R China; [Zhou, Runqi] Chongqing Med Univ, Higher Educ & Stomatol Hosp, Chongqing Municipal Key Lab Oral Biomed Engn, Chongqing 401174, Peoples R China"

通信作者："Ma, JF; Lin, JX (通讯作者)，Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325027, Peoples R China.; Wen, CE (通讯作者)，RMIT Univ, Ctr Addit Mfg, Sch Engn, Melbourne, Vic 3001, Australia.; Zhou, RQ (通讯作者)，Chongqing Med Univ, Higher Educ & Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401174, Peoples R China.; Zhou, RQ (通讯作者)，Chongqing Med Univ, Higher Educ & Stomatol Hosp, Chongqing Municipal Key Lab Oral Biomed Engn, Chongqing 401174, Peoples R China."

来源：CHEMICAL ENGINEERING JOURNAL

ESI学科分类：ENGINEERING

WOS号：WOS:001263716900001

JCR分区：Q1

影响因子：15.1

年份：2024

卷号：493

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Biodegradable Zn-Ag metal; GBRM; Mechanical property; Osteogenesis; scandium (Sc); Subcutaneous infection model

摘要："Zinc-silver (Zn-Ag) alloys are generally promising guided bone-regeneration membrane (GBRM) materials due to their moderate degradability, osteogenic differentiation, and antibacterial properties. However, Zn-Ag alloys often display microstructural inhomogeneity and mechanical instability due to the formation of coarse Ag-rich second phases. In this study, Zn-4Ag and Zn-4Ag-0.1Sc (denoted ZA and ZAS, respectively) were comparatively investigated, and the ZAS exhibited a suitable degradation rate, high strength-elongation product, cytocompatibility, antibacterial capacity, and in vitro and in vivo osteogenic properties, making it highly appropriate for GBRM applications. Among all the as-cast and hot-rolled (HR) samples, the HR ZAS had the highest ultimate tensile strength of -260.5 MPa, tensile yield strength of -202.0 MPa, and elongation of -72.7%. The HR ZAS also exhibited a higher degradation rate of -36.5 mu m/a in Hanks' solution than those of the HR ZA, while its diluted extract was more cytocompatible and capable of osteogenic differentiation toward both MG-63 and MC3T3-E1 cells. The HR ZAS showed an exceptionally effective antibacterial ability against S. aureus in both in vitro antibacterial testing and in vivo subcutaneous infection models. Further, the HR ZAS demonstrated better osteogenic and histocompatibility properties than those of pure Zn in a rat skull defect model."

基金机构："Zhejiang Public Welfare Technology Application Research Project of China [LTGY24H140002, LTGY23H140002, LGF22H140008]; Australian Research Council through the Discovery Project [DP240101131]"

基金资助正文："The work was supported by the Zhejiang Public Welfare Technology Application Research Project of China (No. LTGY24H140002, No. LTGY23H140002, No. LGF22H140008) . C. W. and Y. L. also acknowledge the financial support for this research by the Australian Research Council through the Discovery Project (DP240101131) ."