Impact of pre-treatment extracellular volume fraction measured by computed tomography on response of primary lesion to preoperative chemotherapy in abdominal neuroblastoma

作者全名："Wang, Haoru; Chen, Xin; Xie, Mingye; Qin, Jinjie; Li, Ting; He, Ling"

作者地址："[Wang, Haoru; Chen, Xin; Xie, Mingye; Qin, Jinjie; Li, Ting; He, Ling] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Child Neurodev & Cognit Disorder, Minist Educ,Key Lab Child Dev & Disorders,Dept Rad, Chongqing, Peoples R China"

通信作者："He, L (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Child Neurodev & Cognit Disorder, Minist Educ,Key Lab Child Dev & Disorders,Dept Rad, Chongqing, Peoples R China."

来源：CLINICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001265578700001

JCR分区：Q2

影响因子：2.7

年份：2024

卷号：79

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Neuroblastoma; Extracellular Volume Fraction; Preoperative Chemotherapy; Computed Tomography

摘要："Objectives: To retrospectively investigate the impact of pre-treatment Extracellular Volume Fraction (ECV) measured by Computed Tomography (CT) on the response of primary lesions to preoperative chemotherapy in abdominal neuroblastoma. Methods: A total of seventy-five patients with abdominal neuroblastoma were retrospectively included in the study. The regions of interest for the primary lesion and aorta were determined on unenhanced and equilibrium phase CT images before treatment, and their average CT values were measured. Based on patient hematocrit and average CT values, the ECV was calculated. The correlation between ECV and the reduction in primary lesion volume was examined. A receiver operating characteristic curve was generated to assess the predictive performance of ECV for a very good partial response of the primary lesion. Results: There was a negative correlation between primary lesion volume reduction and ECV (r = -0.351, p = 0.002), and primary lesions with very good partial response had lower ECV (p < 0.001). The area under the curve for ECV in predicting the very good partial response of primary lesion was 0.742 (p < 0.001), with a 95 % Confidence Interval of 0.628 to 0.836. The optimal cut-off value was 0.28, and the sensitivity and specificity were 62.07 % and 84.78 %, respectively. Conclusions: The measurement of pre-treatment ECV on CT images demonstrates a significant correlation with the response of the primary lesion to preoperative chemotherapy in abdominal neuroblastoma."

基金机构：Natural Science Foundation Chongqing [CSTB 2023NSCQ-BHX0127]

基金资助正文：Funding The project was funded by the Natural Science Foundation Chongqing (CSTB 2023NSCQ-BHX0127) .