"Biodegradable Zn-Mg-Ce alloys with good mechanical properties, degradability, and cytocompatibility matching for potential load-bearing bone-implant applications"

作者全名："Pan, Li; Nie, Xin; Zhou, Runqi"

作者地址："[Pan, Li; Nie, Xin] Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Wenzhou 325000, Peoples R China; [Pan, Li; Nie, Xin; Zhou, Runqi] Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325000, Peoples R China; [Zhou, Runqi] Chongqing Med Univ, Higher Educ & Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401174, Peoples R China; [Zhou, Runqi] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn, Chongqing 401174, Peoples R China"

通信作者："Nie, X; Zhou, RQ (通讯作者)，Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325000, Peoples R China."

来源：MATERIALS TODAY COMMUNICATIONS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001267492300001

JCR分区：Q2

影响因子：3.8

年份：2024

卷号：40

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Zn-Mg-Ce alloys; Biomaterials; Mechanical properties; Corrosion; Cytocompatibility

摘要："Zinc (Zn) alloys are expected to be a potential biodegradable bone implant material due to its biodegradability, good biological effect, and easy formability. However, the lower mechanical properties and low degradation rate of most cast Zn alloys still make it difficult to match the mechanical properties and healing cycle requirements of degradable bone implants. In this work, the degradable Zn1Mg-xCe (x=0.1, 0.2, and 0.3 wt%) alloys with high comprehensive mechanical properties, suitable degradation rate (CRimm) and cytocompatibility were prepared by cerium (Ce) alloying followed by hot-rolling for load-bearing bone-implant material. With the increase of Ce content, the Zn-1Mg-xCe alloys showed a gradual increase in mechanical strength, hardness, and CRimm and decreased elongation at break and cell viability. Zn-1Mg-0.2Ce exhibited the best comprehensive performance match among all Zn-1Mg-xCe, including a moderate ultimate tensile strength of similar to 263 MPa, yield strength of similar to 171 MPa, elongation at break of similar to 14.4 %, strength-elongation product of similar to 3.8 GPa%, hardness of similar to 90.6 HV, CRimm of similar to 62 mu m/y, and cytocompatibility towards 3T3 cells."

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