Circ-IP6K2 suppresses tumor progression by modulating the miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma

作者全名："Tang, Jian-ying; Yang, Lu; Wu, Qing-Jian; Yang, Ying; Su, Yuan-Yuan; Chen, Yi-Rong; Mu, Jiao"

作者地址："[Tang, Jian-ying; Yang, Lu; Yang, Ying; Su, Yuan-Yuan; Chen, Yi-Rong; Mu, Jiao] Chongqing Med Univ, Univ Town Hosp, Dept Nephrol, 55 Rd Univ Town, Chongqing 401331, Peoples R China; [Wu, Qing-Jian] Third Mil Med Univ, Xinqiao Hosp, Dept Urol, Chongqing 400037, Peoples R China"

通信作者："Mu, J (通讯作者)，Chongqing Med Univ, Univ Town Hosp, Dept Nephrol, 55 Rd Univ Town, Chongqing 401331, Peoples R China."

来源：FUNCTIONAL & INTEGRATIVE GENOMICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001268205700001

JCR分区：Q2

影响因子：2.9

年份：2024

卷号：24

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：miR-1292-5p; Progression; Clear cell renal cell carcinoma

摘要："Renal cell carcinoma (RCC) is a malignant tumor originating from the epithelial cells of the renal tubules. The clear cell RCC subtype is closely linked to a poor prognosis due to its rapid progression. Circular RNA (circRNA) is a novel class of regulatory RNA molecules that play a role in the development of ccRCC, although their functions have not been fully elucidated. In this study, we identified a significant downregulation of circ-IP6K2 in ccRCC tissues based on data from the GSE100186 dataset. The decreased expression of circ-IP6K2 correlated with the progression of TNM stage and histological grade, and was also associated with decreased overall survival rates in ccRCC patients. Moreover, our findings revealed that circ-IP6K2 expression suppressed proliferation, migration, and invasion capabilities in vitro, and inhibited xenograft growth in vivo. Mechanistically, circ-IP6K2 acted as a sponge for miR-1292-5p in ccRCC cells, which in turn targeted the 3'UTR of CAMK2N1, leading to a decrease in its expression. CAMK2N1 was identified as a tumor suppressor that negatively regulated the beta-catenin/c-Myc oncogenic signaling pathway. Additionally, we confirmed a positive correlation between the expression of circ-IP6K2 and CAMK2N1 in ccRCC. Circ-IP6K2 functions to impede the progression of ccRCC by modulating the miR-1292-5p/CAMK2N1 axis. These findings shed new light on the molecular mechanisms driving ccRCC progression and suggest potential therapeutic targets for the treatment of ccRCC."

基金机构："Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission"

基金资助正文：No Statement Available