Lycorine combined with cisplatin synergistically inhibited osteosarcoma cells growth and metastasis by suppressing Wnt/β-Catenin and STAT3 signaling pathways

作者全名："Liu, Xuexue; Ye, Caihong; Feng, Jia; Zhan, Ping; Luo, Qing; Liu, Jinbo"

作者地址："[Liu, Xuexue; Ye, Caihong; Feng, Jia; Luo, Qing; Liu, Jinbo] Southwest Med Univ, Affiliated Hosp, Sichuan Prov Engn Technol Res Ctr Mol Diag Clin Di, Dept Lab Med,Mol Diag Clin Dis Key Lab Luzhou, Luzhou 646000, Peoples R China; [Ye, Caihong] Chongqing Med Univ, Coll Lab Med, Key Lab Diagnost Med Designated Chinese Minist Edu, Chongqing 40016, Peoples R China; [Zhan, Ping] Southwest Med Univ, Sichuan Prov Ctr Gynaecol & Breast Dis, Affiliated Hosp, Luzhou 646000, Peoples R China"

通信作者："Liu, JB (通讯作者)，Southwest Med Univ, Affiliated Hosp, Sichuan Prov Engn Technol Res Ctr Mol Diag Clin Di, Dept Lab Med,Mol Diag Clin Dis Key Lab Luzhou, Luzhou 646000, Peoples R China."

来源：JOURNAL OF FUNCTIONAL FOODS

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001270518700001

JCR分区：Q1

影响因子：5.6

年份：2024

卷号：119

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Osteosarcoma; Lycorine; Cisplatin; Drug combination

摘要："Cisplatin is commonly used in treating osteosarcoma, however, chemoresistance reduces its efficacy and results in a poor prognosis. Lycorine, a Chinese herbal medicine component, possesses anti-tumor and anti-inflammatory properties. This study aims to investigate the combined impact of lycorine and cisplatin on osteosarcoma and its molecular mechanism. The combination of lycorine and cisplatin exhibited a synergistic effect evaluated by MTT and Zheng-Jun Jin's method. Lycorine and cisplatin synergistically inhibit proliferation, migration, invasion, and induce apoptosis of osteosarcoma cells. Pharmacological analysis predicts 13 key targets, including Wnt/ beta-Catenin and STAT3. After treatment with this combination, key molecules in Wnt/beta-Catenin and STAT3 pathways were significantly inhibited. In an orthotopic tumor model, the combination significantly reduces lung metastasis. The present work suggests that a combination of lycorine with cisplatin can effectively inhibit OS cells by suppressing the Wnt/beta-Catenin and STAT3 signaling pathways synergistically. This is expected to enhance the therapeutic effect of OS."

基金机构："Sichuan Science and Technology Program [2022ZHYZ0012, 2022YFS0312]"

基金资助正文：<B>Funding</B> This work was supported by grants from the Sichuan Science and Technology Program (2022ZHYZ0012 and 2022YFS0312) .. Availability of data and materials All data generated or analyzed during this study are available from the corresponding author upon reasonable request.