Miao sour soup alleviates DSS-induced colitis in mice: modulation of gut microbiota and intestinal barrier function

作者全名："Li, Lincao; Sun, Haiyan; Tan, Lunbo; Guo, Hui; He, Lisi; Chen, Jieyu; Chen, Shuting; Liu, Dong; Zhu, Mingjun; Ouyang, Zijun"

作者地址："[Li, Lincao; Sun, Haiyan; Guo, Hui; He, Lisi; Chen, Jieyu; Chen, Shuting; Liu, Dong; Ouyang, Zijun] Shenzhen Polytech Univ, Sch Food & Drug, 7098 Liuxian Ave, Shenzhen 518055, Peoples R China; [Li, Lincao; Zhu, Mingjun; Ouyang, Zijun] South China Univ Technol, Guangzhou Higher Educ Mega Ctr, Guangdong Key Lab Fermentat & Enzyme Engn, Sch Biol & Biol Engn, Guangzhou 510006, Peoples R China; [Tan, Lunbo] Erasmus MC, Dept Internal Med, Div Vasc Med & Pharmacol, Rotterdam, Netherlands; [Tan, Lunbo] Chongqing Med Univ, Women & Childrens Hosp, Chongqing 401147, Peoples R China"

通信作者："Liu, D; Ouyang, ZJ (通讯作者)，Shenzhen Polytech Univ, Sch Food & Drug, 7098 Liuxian Ave, Shenzhen 518055, Peoples R China.; Zhu, MJ; Ouyang, ZJ (通讯作者)，South China Univ Technol, Guangzhou Higher Educ Mega Ctr, Guangdong Key Lab Fermentat & Enzyme Engn, Sch Biol & Biol Engn, Guangzhou 510006, Peoples R China."

来源：FOOD & FUNCTION

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001270694300001

JCR分区：Q1

影响因子：6.1

年份：2024

卷号：15

期号：16

开始页：8370

结束页：8385

文献类型：Article

关键词：　

摘要："Miao sour soup (MSS), a daily fermented food in Guizhou, China, is rich in microorganisms with various beneficial activities, including anti-inflammatory and antioxidant activities. However, the therapeutic effects of MSS on IBD remain unexplored. This study aimed to investigate the protective effect of MSS against colitis in mice. In this study, we examined the microbial community structure of MSS by metagenomic sequencing and also explored the protective effect of MSS on DSS-induced colitis in mice. We investigated the effects of MSS on intestinal inflammatory response and intestinal barrier function in mice. Finally, the changes in intestinal flora were analyzed based on the 16S rRNA gene sequencing results. Significantly, the experiment result shows that MSS ameliorated the severity of DSS-induced disease in mice by mitigating colitis-associated weight loss, reducing the disease activity index of IBD, alleviating colonic hemorrhagic lesions, increasing colon length, and improving colonic tissue damage. Moreover, MSS preserved intestinal barrier integrity and restored intestinal epithelial function in mice. Additionally, MSS modulated the structure and composition of the intestinal flora. Furthermore, MSS downregulated pro-inflammatory factors and attenuated the NF-kappa B p65 expression, thereby mitigating the inflammatory response. These findings highlight the protective effect of MSS against DSS-induced colitis, providing substantial scientific support for potential applications of MSS as a functional food. Miao sour soup (MSS), a daily fermented food in Guizhou, China, is rich in microorganisms with various beneficial activities, including anti-inflammatory and antioxidant activities."

基金机构："Characteristic Innovation Project of Guangdong Provincial Education Department [2023KTSCX320]; Shenzhen Science and Technology Program [20231126130044001, 20220814205518001, 20230731094501002]; Innovation Platform and Innovation Team of Guangdong Education Department [2021CJPT014, 2021KCXTD069]"

基金资助正文："This work was financially supported by the Characteristic Innovation Project of Guangdong Provincial Education Department (No. 2023KTSCX320); Shenzhen Science and Technology Program (No. 20231126130044001, No. 20220814205518001, No. 20230731094501002); Innovation Platform and Innovation Team of Guangdong Education Department (No. 2021CJPT014, 2021KCXTD069)."