"Clinical and immunological features of COVID-19 in patients with anti-MDA5 dermatomyositis during the omicron wave in Chongqing, China"

作者全名："Wu, Na; Chen, Zhiwei; Zha, Guanhua; Deng, Zhiling; Huang, Wenhan; Cai, Dachuan; Peng, Mingli; Hu, Peng; Tang, Lin; Ren, Hong"

作者地址："[Wu, Na; Chen, Zhiwei; Zha, Guanhua; Deng, Zhiling; Cai, Dachuan; Peng, Mingli; Hu, Peng; Ren, Hong] Chongqing Med Univ, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis, Minist Educ,Affiliated Hosp 2, Chongqing, Peoples R China; [Wu, Na; Chen, Zhiwei; Zha, Guanhua; Deng, Zhiling; Cai, Dachuan; Peng, Mingli; Hu, Peng; Ren, Hong] Chongqing Med Univ, Dept Infect Dis, Affiliated Hosp 2, Chongqing, Peoples R China; [Huang, Wenhan; Tang, Lin] Chongqing Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Tang, L (通讯作者)，Chongqing Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China.; Hu, P; Ren, H (通讯作者)，Chongqing Med Univ, Inst Viral Hepatitis, Dept Infect Dis,Affiliated Hosp 2, Key Lab Mol Biol Infect Dis,Minist Educ, 288 Tianwen Ave, Chongqing 401336, Peoples R China."

来源：JOURNAL OF MEDICAL VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001275712800017

JCR分区：Q1

影响因子：12.7

年份：2024

卷号：96

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：adaptive immunity; antibody responses; COVID-19 virus infection; dermatomyositis; SARS-CoV-2 variants

摘要："Patients with anti-melanoma differentiation-associated gene 5 (anti-MDA5) dermatomyositis (DM) have a higher risk of coronavirus disease 2019 (COVID-19) infection. In this longitudinal observational study, we aimed to investigate the clinical and immunological features of these patients after COVID-19 infection. A total of 73 patients with anti-MDA5 DM were recruited from the Second Affiliated Hospital of Chongqing Medical University during the Omicron wave epidemic. Clinical data were collected by questionnaire survey and electronic medical records. Blood samples were used to determine the immunity responses. From December 9, 2022 to March 31, 2023, 67 patients were eligible for final analysis; 68.7% of them were infected with COVID-19. The most common symptoms observed in COVID-19 were upper respiratory symptoms, most cases were mild or moderate (97.8%). The clinical laboratory indexes were relativity stable in patients after infection (all p>0.05). Vaccination is not a protective factor against the Omicron infection (odds ratio: 2.69, 95% confidence interval: 0.81-8.93, p=0.105). Both wildtype (WT) neutralizing antibodies titer and BA.5-specific immunoglobulin G titer were significantly enhanced after infection (all p<0.01), which was as high as healthy controls (HCs). The memory B-cell responses were similar between the patients with anti-MDA5 DM and HCs (p>0.05). However, both the WT-specific CD8(+) T cells and CD4(+) T cells were reduced in patients with anti-MDA5 DM (all p<0.05). In conclusion, patients with anti-MDA5 DM did not deteriorate the COVID-19, in turn, COVID-19 infection did not increase the risk of anti-MDA5 DM exacerbation. The humoral responses were robust but the cellular responses were weakened after COVID-19 infection."

基金机构："Chongqing Postdoctoral Science Foundation Project [CSTB2023NSCQ-BHX0082]; Science and Technology Research Project of Chongqing Education Commission [KJQN202300404]; Second Affiliated Hospital of Chongqing Medical University; First batch of key Disciplines on Public Health in Chongqing, Health Commission of Chongqing, China; Remarkable Innovation Clinical Research Project"

基金资助正文："Chongqing Postdoctoral Science Foundation Project, Grant/Award Number: CSTB2023NSCQ-BHX0082; The Science and Technology Research Project of Chongqing Education Commission, Grant/Award Number: KJQN202300404; Remarkable Innovation Clinical Research Project; The Second Affiliated Hospital of Chongqing Medical University; The First batch of key Disciplines on Public Health in Chongqing, Health Commission of Chongqing, China"