Efficacy and safety of batroxobin in patients with acute ischemic stroke: A multicenter retrospective analysis

作者全名："Liu, Shu; Wang, Shengyuan; Zou, Qian; Pu, Yinshuang; Li, Xiaobo; Hang, Zhenlun; Cai, Zhiyou; Wang, Chuanling"

作者地址："[Liu, Shu; Wang, Shengyuan; Zou, Qian; Pu, Yinshuang; Cai, Zhiyou] Chongqing Gen Hosp, Dept Neurol, 118 Ave Stars, Chongqing 401120, Peoples R China; [Liu, Shu] Southwest Jiaotong Univ, Chengdu Peoples Hosp 3, Dept Neurol, Affiliated Hosp, Chengdu, Peoples R China; [Wang, Shengyuan; Zou, Qian; Pu, Yinshuang; Cai, Zhiyou] Chongqing Key Lab Neurodegenerat Dis, Chongqing, Peoples R China; [Li, Xiaobo] Yubei Dist Hosp Tradit Chinese Med, Dept Neurol, Chongqing, Peoples R China; [Hang, Zhenlun] Banan Dist Hosp Tradit Chinese Med, Dept Neurol, Chongqing, Peoples R China; [Wang, Chuanling] Chongqing Med Univ, Chongqing, Peoples R China"

通信作者："Cai, ZY (通讯作者)，Chongqing Gen Hosp, Dept Neurol, 118 Ave Stars, Chongqing 401120, Peoples R China.; Wang, CL (通讯作者)，Chongqing Med Univ, Sch Basic Med, Dept Pathophysiol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：CNS NEUROSCIENCE & THERAPEUTICS

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001283098400001

JCR分区：Q1

影响因子：5.5

年份：2024

卷号：30

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：acute ischemic stroke; batroxobin; functional outcomes; stroke recurrence

摘要："AimsThe objective of this study was to evaluate the effectiveness of batroxobin in improving functional outcomes and reducing stroke recurrence among patients with acute ischemic stroke beyond the therapeutic time window for thrombolytic therapy.MethodsThis multicenter, retrospective study enrolled 492 patients with acute moderate-to-severe ischemic stroke within 24 h. 238 patients were given standard (basic) therapy. On the basis of standard treatment, 254 patients received an initial intravenous infusion of batroxobin 10 U on day 1, followed by subsequent infusions of batroxobin 5 U on the 3rd and 5th days, respectively.ResultsIn the batroxobin group, 8.3% of patients experienced recurrence stroke, compared to 17.2% in the control group (HR, 0.433; 95% CI, 0.248 to 0.757; p = 0.003). Furthermore, intravenous batroxobin significantly improved the distribution of 90-120 day disability. Moderate-to-severe bleeding events were reported in three patients (1.2%) in the batroxobin group and one patient (0.4%) in the control group (p = 0.369).ConclusionsAmong patients with acute moderate-to-severe ischemic stroke beyond the time window for thrombolytic therapy, treatment with intravenous batroxobin had a lower risk of stroke recurrence and a better recovery of function outcome without increasing bleeding events. Prospective studies are needed to further confirm. Intravenous batroxobin treatment was found to significantly reduce the risk of stroke recurrence and improve functional outcomes for patients with acute ischemic stroke beyond the thrombolytic therapy time window. Additionally, the treatment did not lead to an increase in moderate-to-severe bleeding events.image"

基金机构：Plan for High-level Talent Introduction [2000055]; Chongqing Postdoctoral Science Foundation [CSTB2022NSCQ-BHX0634]

基金资助正文："Plan for High-level Talent Introduction, Grant/Award Number: 2000055; Chongqing Postdoctoral Science Foundation, Grant/Award Number:CSTB2022NSCQ- BHX0634"