Impact of childhood maltreatment on aging: a comprehensive Mendelian randomization analysis of multiple age-related biomarkers

作者全名："Zhang, Zheng; Ren, Hao; Han, Rong; Li, Qiyin; Yu, Jiangyou; Zhao, Yuan; Tang, Liwei; Peng, Yadong; Liu, Ying; Gan, Cheng; Liu, Keyi; Luo, Qinghua; Qiu, Haitang; Jiang, Chenggang"

作者地址："[Zhang, Zheng; Han, Rong; Li, Qiyin; Yu, Jiangyou; Zhao, Yuan; Tang, Liwei; Peng, Yadong; Liu, Ying; Gan, Cheng; Liu, Keyi; Jiang, Chenggang] Chongqing Hlth Ctr Women & Children, Dept Sleep & Psychol, Chongqing 401147, Peoples R China; [Zhang, Zheng; Han, Rong; Li, Qiyin; Yu, Jiangyou; Zhao, Yuan; Tang, Liwei; Peng, Yadong; Liu, Ying; Gan, Cheng; Liu, Keyi; Jiang, Chenggang] Chongqing Med Univ, Women & Childrens Hosp, Dept Sleep & Psychol, Chongqing 401147, Peoples R China; [Ren, Hao] Chongqing Changshou Dist Mental Hlth Ctr, Chongqing 401231, Peoples R China; [Ren, Hao; Luo, Qinghua; Qiu, Haitang] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China"

通信作者："Jiang, CG (通讯作者)，Chongqing Hlth Ctr Women & Children, Dept Sleep & Psychol, Chongqing 401147, Peoples R China.; Jiang, CG (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Sleep & Psychol, Chongqing 401147, Peoples R China.; Qiu, HT (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China."

来源：CLINICAL EPIGENETICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001285376600001

JCR分区：Q1

影响因子：5.7

年份：2024

卷号：16

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Childhood maltreatment; Telomere length; Epigenetic aging; Frailty; Mendelian randomization

摘要："BackgroundChildhood maltreatment (CM) is linked to long-term adverse health outcomes, including accelerated biological aging and cognitive decline. This study investigates the relationship between CM and various aging biomarkers: telomere length, facial aging, intrinsic epigenetic age acceleration (IEAA), GrimAge, HannumAge, PhenoAge, frailty index, and cognitive performance.MethodsWe conducted a Mendelian randomization (MR) study using published GWAS summary statistics. Aging biomarkers included telomere length (qPCR), facial aging (subjective evaluation), and epigenetic age markers (HannumAge, IEAA, GrimAge, PhenoAge). The frailty index was calculated from clinical assessments, and cognitive performance was evaluated with standardized tests. Analyses included Inverse-Variance Weighted (IVW), MR Egger, and Weighted Median (WM) methods, adjusted for multiple comparisons.ResultsCM was significantly associated with shorter telomere length (IVW: beta = - 0.1, 95% CI - 0.18 to - 0.02, pFDR = 0.032) and increased HannumAge (IVW: beta = 1.33, 95% CI 0.36 to 2.3, pFDR = 0.028), GrimAge (IVW: beta = 1.19, 95% CI 0.19 to 2.2, pFDR = 0.040), and PhenoAge (IVW: beta = 1.4, 95% CI 0.12 to 2.68, pFDR = 0.053). A significant association was also found with the frailty index (IVW: beta = 0.31, 95% CI 0.13 to 0.49, pFDR = 0.006). No significant associations were found with facial aging, IEAA, or cognitive performance.ConclusionsCM is linked to accelerated biological aging, shown by shorter telomere length and increased epigenetic aging markers. CM was also associated with increased frailty, highlighting the need for early interventions to mitigate long-term effects. Further research should explore mechanisms and prevention strategies."

基金机构：AI-based Fertility Assessment and Intelligent Decision System for Perinatal Depressive Disorder Development

基金资助正文："We extend our sincere gratitude to the researchers from the UKB for their generous provision of GWAS data, which significantly contributed to the advancement of this study."