Pseudo-Meigs syndrome caused by a rapidly enlarging hydropic leiomyoma with elevated CA125 levels mimicking ovarian malignancy: a case report and literature review

作者全名："Zou, Longquan; Lou, Jinlong; Huang, Haoran; Xu, Lian"

作者地址："[Zou, Longquan; Lou, Jinlong] Zigong Fourth Peoples Hosp, Dept Pathol, Zigong, Sichuan, Peoples R China; [Zou, Longquan] Zigong Acad Med Big Data & Artificial Intelligence, Inst Precis Med, Zigong, Sichuan, Peoples R China; [Lou, Jinlong] Zigong Fourth Peoples Hosp, Dept Gen Surg, Zigong, Sichuan, Peoples R China; [Huang, Haoran] Chongqing Med Univ, Coll Biomed Engn, Chongqing, Peoples R China; [Xu, Lian] Sichuan Univ, West China Univ Hosp 2, Dept Pathol, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Sichuan, Peoples R China"

通信作者："Xu, L (通讯作者)，Sichuan Univ, West China Univ Hosp 2, Dept Pathol, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Sichuan, Peoples R China."

来源：BMC WOMENS HEALTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001285769600001

JCR分区：Q2

影响因子：2.5

年份：2024

卷号：24

期号：1

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结束页：　

文献类型：Article

关键词：Pseudo-Meigs syndrome; Hydropic leiomyoma; CA125

摘要："Pseudo-Meigs syndrome is a rare syndrome characterized by hydrothorax and ascites associated with pelvic masses, and patients occasionally present with elevated serum cancer antigen-125 (CA125) levels. Hydropic leiomyoma (HLM) is an uncommon subtype of uterine leiomyoma characterized by hydropic degeneration and secondary cystic changes. Rapidly enlarging HLMs accompanied by hydrothorax, ascites, and elevated CA125 levels may be misdiagnosed as malignant tumors. Here, we report a case of HLM in a 45-year-old Chinese woman who presented with ascites and hydrothorax. Preoperative abdominopelvic CT revealed a giant solid mass in the fundus uteri measuring 20 x 15 x 12 cm. Her serum CA125 level was elevated to 247.7 U/ml, while her hydrothorax CA125 level was 304.60 U/ml. The patient was initially diagnosed with uterine malignancy and underwent total abdominal hysterectomy and adhesiolysis. Pathological examination confirmed the presence of a uterine hydropic leiomyoma with cystic changes. After tumor removal, the ascites and hydrothorax subsided quickly, with no evidence of recurrence. The patient's serum CA125 level decreased to 116.90 U/mL on Day 7 and 5.6 U/mL on Day 40 postsurgery. Follow-up data were obtained at 6 months, 1 year, and 2 years after surgery, and no recurrence of ascites or hydrothorax was observed. This case highlights the importance of accurate diagnosis and appropriate management of HLM to achieve successful outcomes."

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