A metabolic reprogramming-related gene signature correlates with prognosis and proliferation of BLCA

作者全名："Wu, Yaoxin; Luo, Yi; Li, Tinghao"

作者地址："[Wu, Yaoxin] Chongqing Med Univ, Affiliated Hosp 1, Hlth Management Ctr, Chongqing 400016, Peoples R China; [Luo, Yi; Li, Tinghao] Chongqing Med Univ, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Li, TH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：DISCOVER ONCOLOGY

ESI学科分类：　

WOS号：WOS:001286519900001

JCR分区：Q3

影响因子：2.2

年份：2024

卷号：15

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Metabolic reprogramming; Prognosis; Bladder cancer; NUP205; Proliferation

摘要："Bladder cancer (BLCA) is one of the most frequent urothelium carcinoma, but with poor prognosis due to lack of reliable predictive biomarkers. Metabolic reprogramming involving in various nutrients, and is reported to be closely associated with malignant progression in BLCA. With the use of transcriptome sequencing data profiles of 349 patients from The Cancer Genome Atlas, we established a three-gene glycolysis-related signature to predict the prognosis of BLCA patients. Our signature constructed on the basis of AK3, GALK1 and NUP205 expression, detail features and interactions between these three genes were further explored. We established a nomogram by integrating clinical variables and the risk score. Glycolytic level and proliferation ability were detected to study the role and mechanisms of NUP205 on BLCA. The connections between three genes in our signature were independent. We found our signature gains more value for patients with highly malignant stage. The established nomogram also confirmed that the signature had a eligible clinically predict capacity. After inhibited NUP205 expression, we found the glycolysis level of BLCA cells decreased and proliferation ability suppressed, mainly through AMPK signaling pathway inactivation. Collectively, our study explored a three-gene glycolysis-related signature that predict the prognosis of patients with BLCA, and highlights NUP205 as a potential therapeutic target for inhibiting glycolytic processes and proliferation in BLCA cells."

基金机构："Department of Urology Surgery, Chongqing Medical University, China"

基金资助正文："The authors gratefully acknowledge the assistance of the Department of Urology Surgery, Chongqing Medical University, China."