Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study

作者全名："Cao, Yuting; Zhou, Xiaoying; Yang, Huan"

作者地址："[Cao, Yuting; Zhou, Xiaoying; Yang, Huan] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Dermatol, Childrens Hosp,Minist Educ,Key Lab Child Dev & Dis, Chongqing 400014, Peoples R China; [Zhou, Xiaoying] Chongqing Med Univ, Chongqing Key Lab Child Rare Dis Infect & Immun, Childrens Hosp, Chongqing, Peoples R China"

通信作者："Yang, H (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Dermatol, Childrens Hosp,Minist Educ,Key Lab Child Dev & Dis, Chongqing 400014, Peoples R China."

来源：SKIN RESEARCH AND TECHNOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001286840900001

JCR分区：Q2

影响因子：2.2

年份：2024

卷号：30

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：common warts; flat warts; Mendelian randomization; plantar warts; retrospective study; vitamin D; warts

摘要："BackgroundThe clinical strategy of oral supplementation of Vitamin D (VD) as a preventive and therapeutic measure for warts needs further exploration.MethodsThe clinical data of patients with skin diseases who visited the Children's Hospital affiliated with Chongqing Medical University from February 2018 to June 2024 were collected. The serum VD levels in patients with warts (common warts, flat warts, and plantar warts) and patients with other common skin diseases (atopic dermatitis, psoriasis, alopecia areata, vitiligo, and chronic urticaria) were compared. Two-sample bidirectional Mendelian randomization (MR) analysis was performed to investigate potential causal associations between VD and warts.ResultsThe average serum VD level of children with warts was 23.27 +/- 7.07 ng/mL, which showed no statistically significant difference compared to children with other common skin diseases. The inverse variance weighted (IVW) method analysis indicated a positive causal relationship between VD and warts (Odds Ratio [OR] = 1.86, [95% CI: 1.19-2.92], p = 0.007). Sensitivity analysis did not show any indication of horizontal pleiotropy or heterogeneity. The MR-PRESSO method did not identify any outliers.ConclusionThe levels of serum VD in children with warts do not significantly decrease compared to children with other common skin conditions. The evidence from the MR analysis indicates a positive causal relationship between VD and warts, suggesting caution in supplementing VD for children with warts who have normal or elevated serum VD levels. Further clinical studies are needed for validation in the future."

基金机构：Chongqing Natural Science Foundation [CSTB2023NSCQ-MSX0168]; Children's Hospital Affiliated to Chongqing Medical University [RC05036]

基金资助正文："Children's Hospital Affiliated to Chongqing Medical University, Grant/Award Number: RC05036; Chongqing Natural Science Foundation, Grant/Award Number: CSTB2023NSCQ-MSX0168"