Clinicopathologic and prognostic implications of HOXA gene and its associated long-noncoding RNAs expression in non-small cell carcinoma: A meta-analysis

作者全名："Yang, Yanhui; Huang, Jinyang; Wang, Qi; Li, Ji; Yu, Lei; Xie, Xiaoyang"

作者地址："[Yang, Yanhui; Li, Ji; Yu, Lei; Xie, Xiaoyang] Chongqing Med Univ, Peoples Hosp Neijiang 1, Neijiang Affiliated Hosp, Dept Thorac Surg, Neijiang 641000, Sichuan, Peoples R China; [Huang, Jinyang; Wang, Qi] Chengdu Med Coll, Clin Med Coll, Dept Cardiothorac Surg, Chengdu, Sichuan, Peoples R China"

通信作者："Xie, XY (通讯作者)，Chongqing Med Univ, Peoples Hosp Neijiang 1, Neijiang Affiliated Hosp, Dept Thorac Surg, Neijiang 641000, Sichuan, Peoples R China."

来源：MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001287977800088

JCR分区：Q2

影响因子：1.6

年份：2024

卷号：103

期号：32

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结束页：　

文献类型：Review

关键词：clinicopathological features; HOXA gene; meta-analysis; non-small cell lung cancer; prognosis

摘要："Background: We conducted an investigation into the correlation between HOXA and associated long-noncoding RNAs, along with their clinicopathologic and prognostic features in non-small cell lung cancer (NSCLC). Methods: A comprehensive search across multiple electronic databases, including PubMed and the Web of Science, was conducted to identify relevant studies. The association between HOXA, clinicopathologic parameters, and prognosis was assessed using relative risk (RR) and hazard ratio (HR) with a 95% confidence interval (CI). Data compilation was performed using STATA 12.0 software. Results: A total of 11 trials involving 2058 patients with NSCLC were included in our study. Significant correlations were observed between HOXA-AS2 and TNM stage (III-IV) (RR=2.173, 95% CI: 1.386-5.437, P< 0.05) and HOTTIP and age (>= 60-year-old) (RR=2.628, 95% CI: 1.185-5.829, P< 0.05) and non-smoking (RR=0.387, 95% CI: 0.156-0.959, P< 0.05). The combined results indicated a significant association between HOXA5 and increased overall survival (HR = 0.69, 95% CI = 0.57-0.84, P < .001). Additionally, HOXA-AS2, HOXA11 and HOTTIP were identified as potential independent predictors for poorer OS (HOXA-AS2: HR =3.48, 95% CI = 1.95 to 6.21, P < 0.05; HOXA11: HR=1.39, 95%CI = 1.08 to 1.79, P < 0.05; HOTTIP: HR=2.44, 95%CI = 1.10 to 5.42, P < 0.05). The prognostic significance of HOXA1, HOXA3 and HOXA4 was uncertain (HOXA1: HR=1.40, 95% CI =0.28 to 7.06, P > 0.05; HOXA3: HR=1.20, 95% CI = 0.96 to 1.50, P > 0.05; HOXA4: HR=0.97, 95% CI = 0.77 to 1.23, P > 0.05). Conclusions: The HOXA gene family has some potential to emerge as a novel prognostic factor for NSCLC and is correlated with some clinicopathological parameters such as the TNM stage, age and smoking. However, further meticulously designed prospective studies are warranted to substantiate these findings."

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