Comprehensive survival analysis of oral squamous cell carcinoma patients undergoing initial radical surgery

作者全名："Dong, Linsheng; Xue, Lingli; Cheng, Wei; Tang, Jin; Ran, Jingxuan; Li, Yadong"

作者地址："[Dong, Linsheng; Xue, Lingli; Cheng, Wei; Tang, Jin; Ran, Jingxuan; Li, Yadong] Chongqing Med Univ, Dept Oral & Maxillofacial Surg, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Dong, Linsheng] Chongqing Dent Hosp, Chongqing 400010, Peoples R China"

通信作者："Li, YD (通讯作者)，Chongqing Med Univ, Dept Oral & Maxillofacial Surg, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：BMC ORAL HEALTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001288273300003

JCR分区：Q1

影响因子：2.9

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Oral squamous cell carcinoma; Survival rate; Prognosis; Factors; Oesophageal squamous cell carcinoma

摘要："Objective This study was designed to evaluate the five-year overall survival (OS) rate and postoperative survival time of patients diagnosed with oral squamous cell carcinoma (OSCC), as well as examine the clinical and pathological factors influencing survival outcomes in OSCC patients. Methods Data were collected from OSCC patients who underwent their first radical surgical intervention in the Department of Maxillofacial Surgery at the First Affiliated Hospital of Chongqing Medical University between April 2014 and December 2016. Follow-up was conducted until March 2022. Results The study included a total of 162 patients. The observed 5-year OS rate was 59.3%. Approximately 45.7% of OSCC patients experienced postoperative recurrence or metastasis, with a 5-year overall disease-free survival rate of 49.4%. There was no significant difference in the impact of sex, age, smoking, alcohol consumption, primary tumour location, depth of invasion or primary tumour size on the 5-year survival rate (p > 0.05). Univariate analysis revealed that clinical stage (Hazard Ratio = 2.239, p = 0.004), perineural invasion (PNI) (Hazard Ratio = 1.712, p = 0.03), lymph node metastasis (pN) (Hazard Ratio = 2.119, p = 0.002), pathological differentiation (Hazard Ratio = 2.715, p < 0.001), and recurrence or metastasis (Hazard Ratio = 10.02, p < 0.001) were significant factors influencing survival. Multivariate analysis further indicated that pathological differentiation (Hazard Ratio = 2.291, p = 0.001), PNI (Hazard Ratio = 1.765, p = 0.031) and recurrence or metastasis (Hazard Ratio = 9.256, p < 0.001) were independent risk factors of survival. Intriguingly, 11 OSCC patients were diagnosed with oesophageal squamous cell carcinoma (ESCC) within 1-4 years following surgery. Conclusion The survival prognosis of OSCC patients is significantly associated with clinical stage, PNI, lymph node metastasis, pathological differentiation, and recurrence or metastasis. Pathological differentiation, PNI and recurrence or metastasis are independent risk factors affecting survival. Routine clinical screening for ESCC may be recommended for OSCC patients with a history of alcohol consumption and tobacco use."

基金机构："Chongqing Municipal Public Health Bureau, Chongqing People's Municipal Government"

基金资助正文：Not applicable.