"Overcoming treatment resistance in cholangiocarcinoma: current strategies, challenges, and prospects"

作者全名："Wang, Jiayi; Liu, Siyan; Cao, Yi; Chen, Yong"

作者地址："[Wang, Jiayi; Liu, Siyan] Chongqing Med Univ, Int Med Coll, Chongqing, Peoples R China; [Cao, Yi] Chongqing Med Univ, Clin Coll 2, Chongqing, Peoples R China; [Chen, Yong] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing, Peoples R China"

通信作者："Chen, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing, Peoples R China."

来源：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001290940100001

JCR分区：Q1

影响因子：5.5

年份：2024

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：resistance in cholangiocarcinoma; targeted therapies; treatment of cholangiocarcinoma; single-cell and spatial transcriptomic perspective; cholangiocarcinoma (CCA)

摘要："Significant advancements in our understanding and clinical treatment of cholangiocarcinoma (CCA) have been achieved over the past 5 years. Groundbreaking studies have illuminated the immune landscape and pathological characteristics of the tumor microenvironment in CCA. The development of immune- and metabolism-based classification systems has enabled a nuanced exploration of the tumor microenvironment and the origins of CCA, facilitating a detailed understanding of tumor progression modulation. Despite these insights, targeted therapies have not yet yielded satisfactory clinical results, highlighting the urgent need for innovative therapeutic strategies. This review delineates the complexity and heterogeneity of CCA, examines the current landscape of therapeutic strategies and clinical trials, and delves into the resistance mechanisms underlying targeted therapies. Finally, from a single-cell and spatial transcriptomic perspective, we address the challenge of therapy resistance, discussing emerging mechanisms and potential strategies to overcome this barrier and enhance treatment efficacy."

基金机构：　

基金资助正文："The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article."