Risk factors for necrotizing enterocolitis in small-for-gestational-age infants: a matched case-control study

作者全名："Ding, Xiang-Ping; Hu, Xiang-Wen; Chen, Shi; Guo, Lu; Wang, Zheng-Li; He, Yu; Li, Lu-Quan; Tang, Wen-Yan"

作者地址："[Ding, Xiang-Ping; Hu, Xiang-Wen; Wang, Zheng-Li; Li, Lu-Quan; Tang, Wen-Yan] Chongqing Med Univ, Dept Neonatol, Childrens Hosp, Jiangxi Hosp, Nanchang 330103, Peoples R China; [Chen, Shi; Guo, Lu; Wang, Zheng-Li; He, Yu; Li, Lu-Quan] Chongqing Med Univ, Chongqing Int Sci & Technol Cooperat Ctr Child Dev, Neonatal Diag & Treatment Ctr, Key Lab Pediat Chongqing,Childrens Hosp, Chongqing 400014, Peoples R China; [Tang, Wen-Yan] Nanchang Med Coll, Jiangxi Maternal & Child Hlth Hosp, Maternal & Child Hlth Hosp, Nan Chan 330038, Jiangxi, Peoples R China"

通信作者："Tang, WY (通讯作者)，Chongqing Med Univ, Dept Neonatol, Childrens Hosp, Jiangxi Hosp, Nanchang 330103, Peoples R China.; Tang, WY (通讯作者)，Nanchang Med Coll, Jiangxi Maternal & Child Hlth Hosp, Maternal & Child Hlth Hosp, Nan Chan 330038, Jiangxi, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:001292901700039

JCR分区：Q1

影响因子：4.6

年份：2024

卷号：14

期号：1

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结束页：　

文献类型：Article

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摘要："Few studies have focused on the risk factors for necrotizing enterocolitis (NEC) in small for gestational age (SGA) infants. The aim of this study was to identify the risk factors for NEC in SGA newborns. This study included consecutive SGA neonates admitted to a tertiary hospital in Jiangxi Province, China from Jan 2008 to Dec 2022. Patients with NEC (Bell's stage >= II) were assigned to the NEC group. Gestational age- and birth weight-matched non-NEC infants born during the same period at the same hospital were assigned to the control group. The risk factors associated with NEC were analyzed with univariate and logistic regression models. During the study period, 2,912 SGA infants were enrolled, 150 (5.15%) of whom developed NEC. In total, 143 patients and 143 controls were included in the NEC and control groups, respectively. Logistic regression analysis revealed that sepsis (OR 2.399, 95% CI 1.271-4.527, P = 0.007) and anemia (OR 2.214, 95% CI 1.166-4.204, P = 0.015) might increase the incidence of NEC in SGA infants and that prophylactic administration of probiotics (OR 0.492, 95% CI 0.303-0.799, P = 0.004) was a protective factor against NEC. Therefore, sepsis, anemia and a lack of probiotic use are independent risk factors for NEC in SGA infants."

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