Clinical characteristics and prognosis of non-high-risk patients with incidental stage T1 lung cancer: A prospective cohort study

作者全名："Peng, Mingyu; Li, Weiyi; Dai, Haiyun; Ao, Min; Chen, Jinfeng; Liu, Ao; Wang, Heng; Yao, Shiyi; Yang, Li"

作者地址："[Peng, Mingyu; Li, Weiyi; Dai, Haiyun; Ao, Min; Chen, Jinfeng; Liu, Ao; Yao, Shiyi; Yang, Li] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China; [Peng, Mingyu; Li, Weiyi; Dai, Haiyun; Ao, Min; Chen, Jinfeng; Liu, Ao; Yang, Li] Chongqing Key Lab Precis Med & Prevent Major Resp, Chongqing 400037, Peoples R China; [Wang, Heng] Chongqing Med Univ, Sch Basic Med Sci, Dept Bioinformat, Chongqing 400016, Peoples R China; [Yang, Li] Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Yang, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China.; Yang, L (通讯作者)，Chongqing Key Lab Precis Med & Prevent Major Resp, Chongqing 400037, Peoples R China.; Yang, L (通讯作者)，Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Youyi Rd, Chongqing 400016, Peoples R China."

来源：CLINICAL AND EXPERIMENTAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001295918900001

JCR分区：Q2

影响因子：4.6

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Pulmonary Nodules; Stage T1 Lung Cancer; Incidental; Non-high-risk; US preventative services task force (USPSTF)

摘要："Objectives There is currently no evidence documenting the clinical characteristics and prognosis of non-high-risk patients with incidental stage T1 lung cancer (LC). The aim of this study was to investigate the clinical characteristics and prognosis of non-high-risk patients with incidental stage T1 LC. Methods This prospective cohort study included patients with incidental stage T1 LC who were diagnosed pathologically at the First Affiliated Hospital of Chongqing Medical University between 1st Jan 2019 and 31st Dec 2023. The follow-up time for all participants concluded on 31st Jan 2024, or upon death. All included patients were divided into non-high-risk (observation) and high-risk (control) groups based on the 2021 US preventative services task force recommendations. The primary outcomes were overall survival probability and LC-specific survival probability. The secondary outcomes were clinical characteristics, including demographic variables, histological types and TNM staging. Results We studied 1876 patients with incidental stage T1 LC. Of these, 1491 (79.48%) non-high-risk patients were included in the observation group, and the remaining 385 (20.52%) high-risk patients composed the control group. The follow-up interval was between 0 and 248 months for all participants, with a median time of 41.64 +/- 23.85 months. The patients in the observation group were younger and had smaller tumors, more adenocarcinomas, and earlier disease stages than those in the control group (p <= 0.001). The overall survival probability (HR = 0.23, [95% CI: 0.18, 0.31], p < 0.001) and the LC-specific survival probability (HR = 0.23, [95% CI: 0.17, 0.31], p < 0.001) for the patients in the observation group were also both higher than those in the control group. The results appeared to be consistent across important subgroups. Conclusion In this study, non-high-risk patients with incidental stage T1 LC were younger, had smaller tumors, had more adenocarcinomas, had a lower probability of metastasis, and had longer survival than did high-risk patients."

基金机构：National Natural Science Foundation of China

基金资助正文：We appreciate the work of all health-care workers involved in the diagnosis and treatment of patients in the First Affiliated Hospital of Chongqing Medical University. We are grateful to all patients involved in the study.