Causal factors for osteoarthritis risk revealed by mendelian randomization analysis

作者全名："Luo, Qingfeng; Zhang, Shiyong; Yang, Qiyuan; Deng, Yuyi; Yi, Hengjing; Li, Xingsheng"

作者地址："[Luo, Qingfeng; Yang, Qiyuan; Deng, Yuyi] Chongqing Med Univ, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China; [Luo, Qingfeng; Yang, Qiyuan; Deng, Yuyi; Yi, Hengjing; Li, Xingsheng] Chongqing Med Univ, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China; [Luo, Qingfeng; Yang, Qiyuan; Deng, Yuyi; Yi, Hengjing; Li, Xingsheng] Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr, Chongqing 400010, Peoples R China; [Zhang, Shiyong] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Joint Surg, Guangzhou 510080, Guangdong, Peoples R China"

通信作者："Li, XS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China.; Li, XS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr, Chongqing 400010, Peoples R China."

来源：AGING CLINICAL AND EXPERIMENTAL RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001296557900002

JCR分区：Q2

影响因子：4

年份：2024

卷号：36

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Osteoarthritis; Mendelian randomization; Causality; Genetics

摘要："Osteoarthritis (OA), a prevalent chronic disease among the elderly, presents a complex pathogenesis and currently lacks effective treatment. Traditional observational studies are time-consuming, labor-intensive, susceptible to confounding factors, and cannot establish causal relationships. Mendelian randomization (MR) analysis, leveraging genetic variation to assess causal associations between exposures and outcomes, offers a cost-effective and efficient alternative. Over the past decade, large-scale genome-wide association studies have identified numerous genetic variants linked to OA risk factors, facilitating MR study design. In this review, we systematically identified 52 MR studies meeting specific criteria and evaluated their quality, exploring the impact of lifestyle, nutrition, comorbidities, circulating metabolites, plasma proteins, and other health factors on OA risk. We discuss the results and potential mechanisms of MR findings, addressing conflicting evidence based on existing literature and our prior research. With the ongoing expansion of genome-wide association data, we anticipate MR's role in future OA studies to broaden, particularly in drug development research using targeted MR approaches. We thus aim for this paper to offer valuable insights for researchers and clinicians in related fields."

基金机构："the Program for Youth Innovation in Future Medicine, Chongqing Medical University; Program for Youth Innovation in Future Medicine, Chongqing Medical University [2023NSCQ-MSX0742]; Natural Science Foundation of Chongqing"

基金资助正文："This study was supported by the Program for Youth Innovation in Future Medicine, Chongqing Medical University (no.w0155) and the Natural Science Foundation of Chongqing (no. 2023NSCQ-MSX0742)."