Clinical value of prokineticin 2 in the diagnosis of neonatal necrotizing enterocolitis

作者全名："Zeng, Qiuli; Zeng, Li; Yu, Xiaoyan; Yuan, Xi; Ma, Wenjing; Song, Zhixin; Chen, Dapeng"

作者地址："[Zeng, Qiuli; Zeng, Li; Yu, Xiaoyan; Yuan, Xi; Ma, Wenjing; Song, Zhixin; Chen, Dapeng] Chongqing Med Univ, Childrens Hosp, Dept Clin Lab, 136 Zhongshaner Rd, Chongqing 400014, Peoples R China; [Zeng, Qiuli; Zeng, Li; Yu, Xiaoyan; Yuan, Xi; Ma, Wenjing; Song, Zhixin; Chen, Dapeng] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Zeng, Qiuli; Zeng, Li; Yu, Xiaoyan; Yuan, Xi; Ma, Wenjing; Song, Zhixin; Chen, Dapeng] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Zeng, Qiuli; Zeng, Li; Yu, Xiaoyan; Yuan, Xi; Ma, Wenjing; Song, Zhixin; Chen, Dapeng] Chongqing Key Lab Child Infect & Immun, Chongqing, Peoples R China"

通信作者："Song, ZX; Chen, DP (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Clin Lab, 136 Zhongshaner Rd, Chongqing 400014, Peoples R China."

来源：BIOMARKERS

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001297141500001

JCR分区：Q3

影响因子：2.6

年份：2024

卷号：29

期号：6

开始页：361

结束页：367

文献类型：Article

关键词：Necrotizing enterocolitis; prokineticin 2; biomarker; diagnosis; prognosis

摘要："Background: Necrotizing enterocolitis (NEC) is an inflammatory and necrotizing intestinal emergency that occurs in preterm infants and low birth weight newborns; however, no specific serum biomarkers for the diagnosis of NEC has been identified so far. Methods: Serum samples were collected from healthy neonatal controls and patients with NEC newly admitted to the Children's Hospital of Chongqing Medical University. ELISA was used to measure serum PK2 levels, and ROC curve analysis was sued to evaluate the diagnostic efficacy of PK2 and other clinical biomarkers. Results: Serum PK2 levels in the NEC group (n = 53) were significantly lower than those in the control group (n = 18), but increased to near-normal levels after the postoperative recovery period. The NLR value of NEC group was higher than that of control group (P < 0.05). There was no significant difference in WBC and PLT count between NEC group and control group (P > 0.05). Serum CRP and PCT levels in NEC group were significantly higher than those in control group (P < 0.001 for CRP and P < 0.05 for PCT, respectively). After surgery, serum CRP, NLR and PCT levels were lower than before surgery, while serum PK2 levels were higher than before surgery (P < 0.05). The areas under the ROC curve (AUC) of PK2, PCT and CRP for the diagnosis of NEC were 0.837, 0.662 and 0.552, respectively. The AUC of PK2 combined with PCT, PK2 combined with CRP, and PK2 combined with PCT and CRP were 0.908, 0.854 and 0.981, respectively. PK2 exhibited the highest diagnostic efficacy for NEC. Conclusion: PK2 has higher diagnostic efficacy than PCT and CRP in the diagnosis of NEC; the combination of PK2 and PCT or CRP can significantly improve its diagnostic efficiency, especially when the three are combined at the same time."

基金机构：National Natural Science Foundation of China [82272399]; CQMU (Chongqing Medical University) Program for Youth innovation in Future Medicine; Distinguished Young Scholars of the Children's Hospital of Chongqing Medical University

基金资助正文："This work was supported, in part, by the National Natural Science Foundation of China (Grant Number: 82272399 to Prof. Chen), CQMU (Chongqing Medical University) Program for Youth innovation in Future Medicine (to Prof. chen) and Distinguished Young Scholars of the Children's Hospital of Chongqing Medical University (to Dr. song)."