"The gut-facial aging axis: A two-sample Mendelian randomization and mediation analysis of gut microbiota, gut microbiota metabolic pathways, and blood metabolites"

作者全名："Yang, Sha; Zhao, Ying; Liu, Jian; Song, Jianning; Long, Qingyan; Cheng, Si"

作者地址："[Yang, Sha; Liu, Jian] Guizhou Univ, Med Coll, Guiyang, Guizhou, Peoples R China; [Long, Qingyan; Cheng, Si] Chongqing Med Univ, Affiliated Hosp 2, Dept Orthoped, Chongqing 400010, Peoples R China; [Liu, Jian] Guizhou Prov Peoples Hosp, Dept Neurosurg, Guiyang, Peoples R China; [Song, Jianning] GuiQian Int Gen Hosp, Intervent Dept, Guiyang, Peoples R China; [Zhao, Ying] GuiQian Int Gen Hosp, Dept Orthoped, Guiyang, Peoples R China"

通信作者："Long, QY; Cheng, S (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Orthoped, Chongqing 400010, Peoples R China."

来源：SKIN RESEARCH AND TECHNOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001297351700001

JCR分区：Q2

影响因子：2.2

年份：2024

卷号：30

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：blood metabolites; facial aging; gut microbiota; gut microbiota metabolic pathways; mediation analysis; Mendelian randomization

摘要："Background Facial aging (FA) is a complex process influenced by both genetic and environmental factors. Gut microbiota (GM), gut microbiota metabolic pathways (GMMPs), and blood metabolites (BMs) have been implicated in the regulation of FA, but the causal and mediating effects of these factors remain unclear. Methods We used summary-level data from genome-wide association studies (GWAS) of 16S rRNA gene sequencing data for GM (n = 18 340), GWAS of GMMPs (n = 7738), BMs (n = 24 925), and GWAS of FA (n = 423 999). We applied Mendelian randomization (MR) methods to estimate the causal effects of GM, GMMPs, and BMs on FA. We performed mediation analysis to quantify the proportion of the effects mediated by blood metabolites. Results We identified nine genus, two phylum, two families of GM, nine GM metabolic pathways, and 73 BMs that showed potential causal effects on FA. After Bonferroni correction, three BMs remained causally associated with FA, including average number of methylene groups per double bond (beta, -0.023; 95% CI, -0.032 similar to-0.014; p = 3.120x10-7) and average number of methylene groups in a fatty acid chain (beta, -0.031; 95% CI, -0.045 similar to-0.016; p = 2.062x10-5), which had strong negative causal effects on FA, and ratio of bisallylic groups to total fatty acids (beta, 0.023; 95% CI, 0.017 similar to-0.029; p = 8.441x10-15), which had a strong positive causal effect on FA. Mediation analysis revealed that histidine, average number of methylene groups in a fatty acid chain, and triglycerides in chylomicrons and largest VLDL particles mediated the effects of anaerofilum and/ or superpathway of Laspartate and Lasparagine biosynthesis on FA. Conclusion Our study provides novel insights into the causal and mediating effects of GM, GMMPs, and BMs on FA. These findings may have implications for the development of new strategies for preventing or delaying FA."

基金机构：　

基金资助正文：Not applicable.