Association between the geriatric nutritional risk index and cognitive functions in older adults: a cross-sectional study from National Health and Nutrition Examination Survey
作者全名:"Tan, Zhichun; Nie, Yaxin; Yan, Ning"
作者地址:"[Tan, Zhichun; Nie, Yaxin; Yan, Ning] Chongqing Med Univ, Univ Town Hosp, Neurol Dept, Chongqing, Peoples R China"
通信作者:"Yan, N (通讯作者),Chongqing Med Univ, Univ Town Hosp, Neurol Dept, Chongqing, Peoples R China."
来源:FRONTIERS IN NUTRITION
ESI学科分类:CLINICAL MEDICINE
WOS号:WOS:001300399300001
JCR分区:Q2
影响因子:5
年份:2024
卷号:11
期号:
开始页:
结束页:
文献类型:Article
关键词:cross-sectional study; geriatric nutritional risk index; older adults; cognitive function; nutritional status; NHANES
摘要:"Objective: To investigate the associations between the geriatric nutritional risk index (GNRI) with cognitive functions among U.S. older adults. (Patients were classified into two nutrition risk groups based on the GNRI). Methods: Our analysis utilized data from the cross-sectional National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2014. Cognitive function was measured using CERAD test, AFT and DSST. Composite z-scores were obtained by summing test-specific z-scores of the above three cognitive tests and were used to assess the global cognitive function. We employed weighted logistic regression models to evaluate the associations between GNRI and nutritional status (low and high GNRI) with cognitive function among older participants. The non-linear relationship was described using fitted smoothed curves and threshold effect analyses. Subgroup analysis and interaction tests were also conducted. Results: This study included 2,592 older participants aged 60 years and older. After adjusting for confounding variables, the GNRI was positively associated with AFT (beta = 0.05, 95% CI 0.005-0.096, p-value = 0.0285), DSST (beta = 0.192, 95% CI 0.078-0.305, p-value = 0.0010) and the composite z-scores (beta = 0.027, 95% CI 0.010-0.044, p-value = 0.0024). The results also showed that the high-GNRI group was significantly associated with AFT (beta = 0.922, 95% CI 0.166-1.677, p-value = 0.0169), DSST (beta = 2.791, 95% CI 0.884-4.698, p-value = 0.0042) and composite z-scores (beta = 0.405, 95% CI 0.115-0.695, p-value = 0.0062) likewise had significant positive correlations, using the low-GNRI group as a reference. In addition, inflection points with CERAD and composite z-scores were found at GNRI of 108.016, and 105.371, respectively. Specifically, on the left side of the inflection point GNRI levels were positively correlated with CERAD and composite z-scores (CERAD beta = 0.087, 95% CI 0.024-0.150, p-value = 0.0070; composite z-scores beta = 0.065, 95% CI 0.040-0.091, p-value <0.0001), while on the right side of the inflection point were significantly negatively associated (CERAD beta = -0.295, 95% CI -0.529 to -0.062, p-value = 0.0133, composite z-scores beta = -0.050, 95% CI -0.091 to -0.008, p-value = 0.0184). Conclusion: Lower GNRI was associated with poorer performance in several cognitive domains. Additionally, there was a non-linear positive association between GNRI and cognitive function in normal nutritional states, for excessive GNRI may cause cognitive decline."
基金机构:Chongqing Science and Health Joint Fund Project [2020MSXM095]; Chongqing Municipal Health Commission's First Key Disciplines of Public Health Construction Project
基金资助正文:"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Chongqing Science and Health Joint Fund Project (2020MSXM095) and Chongqing Municipal Health Commission's First Key Disciplines of Public Health Construction Project."