IFITM10 Enhance Tumor Angiogenesis and Promotes Cancer Progression through STAT3 Activation

作者全名："Li, Youjian; Wang, Mengjie; Li, Xun; Jia, Jiehong; Pan, Fei; Li, Wen; Chen, Zhongzhu; Tang, Dianyong; Ou, Kepeng"

作者地址："[Li, Youjian; Jia, Jiehong; Pan, Fei; Li, Wen; Chen, Zhongzhu; Tang, Dianyong; Ou, Kepeng] Chongqing Univ Arts & Sci, Coll Pharm, Natl & Local Joint Engn Res Ctr Targeted & Innovat, IATTI, Chongqing 402160, Peoples R China; [Wang, Mengjie] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China; [Li, Xun] Chongqing Med Univ, Inst Viral Hepatitis, Chongqing 400016, Peoples R China"

通信作者："Ou, KP (通讯作者)，Chongqing Univ Arts & Sci, Coll Pharm, Natl & Local Joint Engn Res Ctr Targeted & Innovat, IATTI, Chongqing 402160, Peoples R China.; Li, X (通讯作者)，Chongqing Med Univ, Inst Viral Hepatitis, Chongqing 400016, Peoples R China."

来源：FRONTIERS IN BIOSCIENCE-LANDMARK

ESI学科分类：　

WOS号：WOS:001301040300004

JCR分区：Q4

影响因子：3.1

年份：2024

卷号：29

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：colorectal cancer; IFITM10; angiogenesis; STAT3 activation

摘要："Background: Humankind have been struggling with colorectal cancer (CRC) for long period with its rapid progression and invasive metastasis. By hyperactivating IL-6/STAT3 signaling, CRC facilitates the capacity of angiogenesis to plunder massive nutrients and develops gradually under harsh condition. Methods: The Cancer Genome Atlas database was analyzed for acquiring interferon-gamma inducible protein 10 (IFITM10) expression levels and their correlation with clinical outcomes. The cell angiogenic ability were assessed by Cell Counting Kit-8 (CCK-8) and tube formation assay. Immunofluorescence, Western blot, and enzyme-linked immunosorbent assay (ELISA) assay were using to assess potential mechanism. Results: In our study, we find that IFITM10 is upregulated in CRC and is positively related with tumor angiogenesis. We also find that IFITM inhibition decreased STAT3 phosphorylation level and IFITM10-mediated angiogenesis depends on STAT3 activation. Furthermore, our data suggests that IFITM10 may be a key prognostic biomarker in colorectal cancer. Conclusion: Together, our study suggests that IFITM10 enhance angiogenesis through STAT3 activation during CRC progression, which highlighting its potency as a therapeutic target for colorectal cancer."

基金机构："Natural Science Foundation of Yongchuan [2023yc-jckx20079]; District Science and Technology Research Program of Chongqing Municipal Education Commission [KJZD-M202101302, KJQN202301322]; Natural Science Foundation of Chongqing, China CSTC [CSTB2023NSCQ-MSX0817]"

基金资助正文："The study was supported by the Natural Science Foundation of Yongchuan (2023yc-jckx20079), District Science and Technology Research Program of Chongqing Municipal Education Commission (KJZD-M202101302, KJQN202301322), Natural Science Foundation of Chongqing, China CSTC (CSTB2023NSCQ-MSX0817)."