Lymph node dissection does not affect the survival of patients with tumor node metastasis stages I and II colorectal cancer

作者全名："He, Fan; Qu, Shu-Pei; Yuan, Ye; Qian, Kun"

作者地址："[He, Fan; Qu, Shu-Pei; Yuan, Ye; Qian, Kun] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Qian, K (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：WORLD JOURNAL OF GASTROINTESTINAL SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001305394800004

JCR分区：Q3

影响因子：2

年份：2024

卷号：16

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：Lymph nodes; Colorectal cancer; T stage; Overall survival; Cox regression analyses

摘要："BACKGROUND The effect of the number of lymph node dissections (LNDs) during radical resection for colorectal cancer (CRC) on overall survival (OS) remains controversial. AIM To investigate the association between the number of LNDs and OS in patients with tumor node metastasis (TNM) stage I-II CRC undergoing radical resection. METHODS Patients who underwent radical resection for CRC at a single-center hospital between January 2011 and December 2021 were retrospectively analyzed. Cox regression analyses were performed to identify the independent predictors of OS at different T stages. RESULTS A total of 2850 patients who underwent laparoscopic radical resection for CRC were enrolled. At stage T1, age [P < 0.01, hazard ratio (HR) = 1.075, 95% confidence interval (CI): 1.019-1.134] and tumour size (P = 0.021, HR = 3.635, 95%CI: 1.210-10.917) were independent risk factors for OS. At stage T2, age (P < 0.01, HR = 1.064, 95%CI: 1.032-1.098) and overall complications (P = 0.012, HR = 2.297, 95%CI: 1.200-4.397) were independent risk factors for OS. At stage T3, only age (P < 0.01, HR = 1.047, 95%CI: 1.027-1.066) was an independent risk factor for OS. At stage T4, age (P < 0.01, HR = 1.057, 95%CI: 1.039-1.075) and body mass index (P = 0. 034, HR = 0.941, 95%CI: 0.890-0.995) were independent risk factors for OS. However, there was no association between LNDs and OS in stages I and II. CONCLUSION The number of LDNs did not affect the survival of patients with TNM stages I and II CRC. Therefore, insufficient LNDs should not be a cause for alarm during the surgery."

基金机构：Chongqing Medical University Future Medical Youth Innovation Team Development Support Program [03030299QC-W0007]

基金资助正文："Supported by Chongqing Medical University Future Medical Youth Innovation Team Development Support Program, No. 03030299QC-W0007"