Associations between Ethylene Oxide Exposure and Liver Function in the US Adult Population

作者全名："Li, Shanshan; Wang, Jinzhou; Lei, Dengliang; Peng, Dadi; Zong, Kezhen; Li, Kaili; Wu, Zhongjun; Liu, Yanyao; Huang, Zuotian"

作者地址："[Li, Shanshan; Lei, Dengliang; Peng, Dadi; Zong, Kezhen; Li, Kaili; Wu, Zhongjun; Liu, Yanyao; Huang, Zuotian] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Wang, Jinzhou] North Sichuan Med Coll, Affiliated Hosp, Nanchong 637000, Peoples R China"

通信作者："Liu, YY; Huang, ZT (通讯作者)，Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：TOXICS

ESI学科分类：　

WOS号：WOS:001306696700001

JCR分区：Q2

影响因子：4.6

年份：2024

卷号：12

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：ethylene oxide; NHANES; liver function test

摘要："Background: Ethylene oxide, a reactive epoxy compound, has been widely used in various industries for many years. However, evidence of the combined toxic effects of ethylene oxide exposure on the liver is still lacking. Methods: We analyzed the merged data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016. Ultimately, 4141 adults aged 18 and over were selected as the sample. We used linear regression to explore the association between blood ethylene oxide and LFT indicators. Results: The weighted linear regression model showed that HbEO is positively correlated with ALP (beta = 2.61, 95% CI 1.97, 3.24, p < 0.0001), GGT (beta = 5.75, 95% CI 4.46, 7/05, p < 0.0001), ALT (beta = 0.50, 95% CI 0.09, 0.90, p = 0.0158), and AST (beta = 0.71, 95% CI 0.44, 0.98, p < 0.0001) and negatively correlated with TBIL (beta = -0.30, 95% CI -0.43, -0.16, p < 0.0001). Conclusions: Ethylene oxide exposure is significantly associated with changes in liver function indicators among adults in the United States. Future work should further examine these relationships."

基金机构：Chongqing Technology Innovation and Application Development Key Project; Chongqing Science and Health Joint Project [2024GGXM005]; Chongqing Research Performance Incentive and Guidance Project [cstc2022jxjl120032]; [cstc2021jscx-gksbX0060]

基金资助正文："This study was supported by Chongqing Technology Innovation and Application Development Key Project (cstc2021jscx-gksbX0060, Zhongjun Wu), Chongqing Science and Health Joint Project (2024GGXM005, Zhongjun Wu), and Chongqing Research Performance Incentive and Guidance Project (cstc2022jxjl120032, Zuotian Huang)."