Targeted anti-angiogenesis therapy for advanced osteosarcoma

作者全名："Zhang, Qiao; Xia, Yuxuan; Wang, Liyuan; Wang, Yang; Bao, Yixi; Zhao, Guo-sheng"

作者地址："[Zhang, Qiao] Army Med Univ, Xinqiao Hosp, Dept Pain & Rehabil, Chongqing, Peoples R China; [Xia, Yuxuan; Bao, Yixi] Chongqing Med Univ, Dept Clin Lab, Affiliated Hosp 2, Chongqing, Peoples R China; [Wang, Liyuan; Zhao, Guo-sheng] Chongqing Med Univ, Dept Spine Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Wang, Yang] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Emergency Med Ctr, Chengdu, Peoples R China"

通信作者："Bao, YX (通讯作者)，Chongqing Med Univ, Dept Clin Lab, Affiliated Hosp 2, Chongqing, Peoples R China.; Zhao, GS (通讯作者)，Chongqing Med Univ, Dept Spine Surg, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001307168500001

JCR分区：Q2

影响因子：4.7

年份：2024

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：advanced osteosarcoma; anti-angiogenesis therapy; mechanism of tumor angiogenesis; proangiogenic factors; comprehensive therapy

摘要："To date, despite extensive research, the prognosis of advanced osteosarcoma has not improved significantly. Thus, patients experience a reduced survival rate, suggesting that a reevaluation of current treatment strategies is required. Recently, in addition to routine surgery, chemotherapy and radiotherapy, researchers have explored more effective and safer treatments, including targeted therapy, immunotherapy, anti-angiogenesis therapy, metabolic targets therapy, and nanomedicine therapy. The tumorigenesis and development of osteosarcoma is closely related to angiogenesis. Thus, anti-angiogenesis therapy is crucial to treat osteosarcoma; however, recent clinical trials found that it has insufficient efficacy. To solve this problem, the causes of treatment failure and improve treatment strategies should be investigated. This review focuses on summarizing the pathophysiological mechanisms of angiogenesis in osteosarcoma and recent advances in anti-angiogenesis treatment of osteosarcoma. We also discuss some clinical studies, with the aim of providing new ideas to improve treatment strategies for osteosarcoma and the prognosis of patients."

基金机构："National Natural Science Foundation of China (NSFC) [82303465]; Natural Science Foundation of Chongqing, China [CSTB2022NSCQ-MSX0103]; Special Financial Aid to the Post doctor Research Project of Chongqing [2022CQBSHTB3079]; China Postdoctoral Science Foundation [2023MD734132]"

基金资助正文："The author(s) declarefinancial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (NSFC) (grant number 82303465), the Natural Science Foundation of Chongqing, China (grant number CSTB2022NSCQ-MSX0103), the Special Financial Aid to the Post doctor Research Project of Chongqing (grant number 2022CQBSHTB3079), and the China Postdoctoral Science Foundation (grant number 2023MD734132)."