A prognostic nomogram for patients with HR plus mucinous breast carcinoma based on the SEER database and a Chinese cohort study

作者全名："Fang, Huiying; Yue, Jian; Li, Hongzhong; Luan, Tiankuo; Wang, Pin; Ren, Guosheng"

作者地址："[Fang, Huiying; Li, Hongzhong; Luan, Tiankuo; Ren, Guosheng] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Key Lab Mol Oncol & Epigenet, Chongqing, Peoples R China; [Fang, Huiying] Chongqing Univ Canc Hosp, Dept Breast Canc Ctr, Chongqing, Peoples R China; [Yue, Jian] Gaozhou Peoples Hosp, Dept Breast Surg, Gaozhou, Peoples R China; [Wang, Pin] Chengdu Third Peoples Hosp, Ctr Breast & Thyroid Surg, Dept Gen Surg, Chengdu, Peoples R China; [Ren, Guosheng] Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing, Peoples R China"

通信作者："Ren, GS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing Key Lab Mol Oncol & Epigenet, Chongqing, Peoples R China.; Ren, GS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001307422500001

JCR分区：Q2

影响因子：4.7

年份：2024

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：SEER; mucinous breast carcinoma; nomogram; propensity score matching analysis; prognosis; neoadjuvant chemotherapy

摘要："Purpose: The study aimed to develop a nomogram model for individual prognosis prediction in patients with hormone receptors positive (HR+) mucinous breast carcinoma (MBC) and assess the value of neoadjuvant chemotherapy (NAC) in this context. Methods: A total of 6,850 HR+ MBC patients from the SEER database were identified and randomly (in a 7:3 ratio) divided into training cohorts and internal validation cohorts. 77 patients were enrolled from the Chongqing University Cancer Hospital as the external validation cohort. Independent risk factors affecting overall survival (OS) were selected using univariate and multivariate Cox regression analysis, and nomogram models were constructed and validated. A propensity score matching (PSM) approach was used in the exploration of the value of NAC versus adjuvant chemocherapy (AC) for long-term prognosis in HR+ MBC patients. Results: Multivariate Cox regression analysis showed 8 independent prognostic factors: age, race, marital status, tumor size, distant metastasis, surgery, radiotherapy, and chemotherapy. The constructed nomogram model based on these 8 factors exhibited good consistency and accuracy. In the training group, internal validation group and external validation group, the high-risk groups demonstrated worse OS (p<0.0001). Subgroup analysis revealed that NAC had no impact on OS (p = 0.18), or cancer specific survival (CSS) (p = 0.26) compared with AC after PSM. Conclusions: The established nomogram model provides an accurate prognostic prediction for HR+ MBC patients. NAC does not confer long-term survival benefits compared to AC. These findings provide a novel approach for prognostic prediction and clinical practice."

基金机构："National Natural Science Foundation of China [82173166, 82372886, 81472475]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0015]; Chongqing Graduate Tutor Team Construction Project, Chongqing Education Commission Foundation [cqmudstd202216]; CQMU Program for Youth Innovation in Future Medicine [W0094]"

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (NO. 82173166, 82372886, and 81472475), Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0015), and Chongqing Graduate Tutor Team Construction Project, Chongqing Education Commission Foundation (cqmudstd202216), and CQMU Program for Youth Innovation in Future Medicine (NO. W0094)."