"Association of social determinants, lifestyle, and metabolic factors with mortality in Chinese adults: A nationwide 10-year prospective cohort study"

作者全名："Lu, Jieli; Li, Mian; He, Jiang; Xu, Yu; Zheng, Ruizhi; Zheng, Jie; Qin, Guijun; Qin, Yingfen; Chen, Yuhong; Tang, Xulei; Ye, Zhen; Xu, Min; Wang, Tiange; Shi, Lixin; Su, Qing; Yu, Xuefeng; Yan, Li; Zhao, Zhiyun; Wan, Qin; Chen, Gang; Gao, Zhengnan; Wang, Guixia; Shen, Feixia; Gu, Xuejiang; Luo, Zuojie; Chen, Li; Hou, Xinguo; Huo, Yanan; Li, Qiang; Qiao, Hong; Zhang, Yinfei; Zeng, Tianshu; Hu, Chunyan; Cao, Qiuyu; Jia, Xiaojing; Liu, Chao; Wang, Youmin; Wu, Shengli; Yang, Tao; Deng, Huacong; Qi, Hongyan; Wu, Xueyan; Zhang, Di; Dai, Meng; Li, Donghui; Lai, Shenghan; Chen, Lulu; Zhao, Jiajun; Mu, Yiming; Hu, Weiguo; Ning, Guang; Hu, Ruying; Bi, Yufang; Wang, Weiqing"

作者地址："[He, Jiang; Cao, Qiuyu; Jia, Xiaojing; Liu, Chao; Wang, Youmin; Wu, Shengli; Yang, Tao; Deng, Huacong; Qi, Hongyan; Wu, Xueyan; Zhang, Di; Dai, Meng; Li, Donghui; Lai, Shenghan; Chen, Lulu; Zhao, Jiajun; Mu, Yiming; Hu, Weiguo; Ning, Guang; Hu, Ruying; Bi, Yufang; Wang, Weiqing; 4C Study Grp] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China; [Lu, Jieli; Li, Mian; Xu, Yu; Zheng, Ruizhi; Zheng, Jie; Chen, Yuhong; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Hu, Chunyan; Cao, Qiuyu; Jia, Xiaojing; Qi, Hongyan; Wu, Xueyan; Zhang, Di; Dai, Meng; Ning, Guang; Bi, Yufang; Wang, Weiqing] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Natl Clin Res Ctr Metab Dis, Shanghai Natl Ctr Translat Med,Sch Med, Shanghai, Peoples R China; [He, Jiang] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA; [Lu, Jieli; Li, Mian; He, Jiang; Xu, Yu; Zheng, Ruizhi; Zheng, Jie; Qin, Guijun; Qin, Yingfen] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Qin, Yingfen] Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China; [Tang, Xulei] Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China; [Ye, Zhen] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China; [Shi, Lixin] Guiyang Med Coll, Affiliated Hosp, Guiyang, Peoples R China; [Su, Qing] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Shanghai, Peoples R China; [Yu, Xuefeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China; [Yan, Li; Chen, Gang] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China; [Wan, Qin] Southwest Med Univ, Affiliated Hosp, Luzhou, Peoples R China; [Gao, Zhengnan] Fujian Med Univ, Fujian Prov Hosp, Fuzhou, Peoples R China; [Gao, Zhengnan] Dalian Municipal Cent Hosp, Dalian, Peoples R China; [Wang, Guixia] First Hosp Jilin Univ, Changchun, Jilin, Peoples R China; [Shen, Feixia; Gu, Xuejiang; Luo, Zuojie] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China; [Chen, Li; Hou, Xinguo; Qiao, Hong] Shandong Univ, Qilu Hosp, Jinan, Peoples R China; [Huo, Yanan] Nanchang Univ, Jiangxi Prov Peoples Hosp, Nanchang, Jiangxi, Peoples R China; [Li, Qiang] Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China; [Zhang, Yinfei] Cent Hosp Shanghai Jiading Dist, Dept Emergency, Shanghai, Peoples R China; [Zeng, Tianshu] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China; [Liu, Chao] Jiangsu Prov Hosp Integrat Chinese & Western Med, Nanjing, Peoples R China; [Wang, Youmin] Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China; [Wu, Shengli] Karamay Municipal Peoples Hosp, Xinjiang, Peoples R China; [Yang, Tao] Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China; [Deng, Huacong] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China; [Li, Donghui] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX USA; [Zhao, Jiajun] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD USA; [Zhao, Jiajun] Shandong Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R China; [Mu, Yiming] Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China; [Hu, Weiguo] Shanghai Jiao Tong Univ, Ruijin Hosp, Med Ctr Aging, Dept Geriatr,Sch Med, Shanghai, Peoples R China"

通信作者："Bi, YF; Wang, WQ (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China."

来源：CELL REPORTS MEDICINE

ESI学科分类：　

WOS号：WOS:001308050900001

JCR分区：Q1

影响因子：14.3

年份：2024

卷号：5

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Nationwide estimates of the impact of common modifiable risk factors on mortality remain crucial. We aim to assess the influence of social determinants, lifestyle, and metabolic factors on mortality in 174,004 adults aged >= 40 years from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. We reveal that 17 modifiable factors are independently associated with mortality, accounting for 64.8% of all-cause mortality, 77.4% of cardiovascular mortality, and 44.8% of cancer mortality. Low education emerges as the leading factor for both all-cause and cancer mortality, while hypertension is predominant for cardiovascular mortality. Moreover, low gross domestic product per capita and high ambient particulate matter with a diameter of <2.5 mm (PM2.5) 2.5 ) air pollution account for 7.8% and 4.3% for all-cause mortality, respectively, using a different method. Gender-specific analyses reveal distinct patterns, with women's mortality primarily associated with social determinants and men exhibiting stronger associations with lifestyle factors. Targeted health interventions are essential to mitigate mortality risks effectively in China."

基金机构："National Key Research and Development Program of China [2022YFC2505202, 2022YFC2505201, 2023YFC2506700, 2021YFA1301103]; National Natural Science Foundation of China [82370810, 91857205, 92157204, 82088102, 82170819]; Science and Technology Commission of Shanghai Municipality [23JS1400900, 23Y11908400, 23XD1422400]; Shanghai Municipal Health Commission [202340084]; Innovative research team of high-level local universities in Shanghai"

基金资助正文："This study was supported by the National Key Research and Development Program of China (grant nos. 2022YFC2505202, 2022YFC2505201, 2023YFC2506700, and 2021YFA1301103), National Natural Science Foundation of China (grant nos. 82370810, 91857205, 92157204, 82088102, and 82170819), Science and Technology Commission of Shanghai Municipality (grant nos. 23JS1400900, 23Y11908400, and 23XD1422400), Shanghai Municipal Health Commission (202340084), and an innovative research team of high-level local universities in Shanghai."