Cognitive frailty in relation to vitamin B12 and 25-hydroxyvitamin D in an elderly population: a cross-sectional study from NHANES

作者全名："Pan, Yu; Tang, Xue Yin; Yang, Juan; Feng, Zhu Qing; Yuan, Yan; Jiang, Yi; Hu, Gui Ming; Dong, Jiang Chuan"

作者地址："[Pan, Yu; Tang, Xue Yin; Feng, Zhu Qing; Yuan, Yan; Jiang, Yi; Hu, Gui Ming] Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr, Chongqing, Peoples R China; [Yang, Juan] Chongqing Med Univ, Affiliated Hosp 1, Dept Integrated Chinese & Western Med, Chongqing, Peoples R China; [Dong, Jiang Chuan] Chongqing Med Univ, Affiliated Hosp 2, Dept Integrated Chinese & Western Med, Chongqing, Peoples R China"

通信作者："Dong, JC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Integrated Chinese & Western Med, Chongqing, Peoples R China."

来源：FRONTIERS IN NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001308128300001

JCR分区：Q2

影响因子：5

年份：2024

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：cognitive frailty; 25-hydroxyvitamin D; vitamin B12; cross-sectional study; NHANES

摘要："Background Nutritional support has been identified as a potential intervention for cognitive frailty; however, the association between 25-hydroxyvitamin D [25-(OH)D], vitamin B12, and cognitive frailty remains ambiguous.Methods This study utilized data from two cycles (2011-2012, 2013-2014) of the National Health and Nutrition Examination Survey (NHANES) to investigate this relationship. The researchers constructed a 41-item frailty index encompassing diverse aspects of physical functioning, psychological evaluation, and medical conditions, and evaluated each participant individually. The study utilized Spearman's rank correlation coefficient and univariate ordered logistic regression to assess the relationships between variables and cognitive frailty. Recursive feature elimination and cross-validation methods were employed to identify the most influential variables for building and optimizing multivariate ordered logistic regression models. Subgroup analyses and interaction tests were further conducted to validate the identified correlations.Results The findings of this study confirm a negative linear correlation between 25-(OH)D levels and cognitive frailty in older adults. Specifically, a one-unit increase in 25-(OH)D levels was associated with a 12% reduction in the risk of cognitive frailty. The result was further supported by subgroup analyses and interaction tests.Conclusion The existence of a negatively correlated linear association between 25-(OH)D levels and cognitive frailty in older adults is plausible, but further rigorously designed longitudinal studies are necessary to validate this relationship."

基金机构："Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission10.13039/501100012669"

基金资助正文："The authors appreciate all the researchers, staff, and involved patients of NHANES databases."