Association of COVID-19 infection and the risk of new incident diabetes: a systematic review and meta-analysis

作者全名："Zhou, Jingye; Wang, Yuzhu; Xu, Ruolan"

作者地址："[Zhou, Jingye; Wang, Yuzhu; Xu, Ruolan] Chongqing Med Univ, Int Med Coll, Chongqing, Peoples R China; [Zhou, Jingye; Wang, Yuzhu; Xu, Ruolan] Univ Leicester, Coll Life Sci, Leicester, England"

通信作者："Zhou, JY (通讯作者)，Chongqing Med Univ, Int Med Coll, Chongqing, Peoples R China.; Zhou, JY (通讯作者)，Univ Leicester, Coll Life Sci, Leicester, England."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001308445700001

JCR分区：Q2

影响因子：5.2

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：COVID-19; long COVID; SARS-CoV-2; diabetes mellitus; public health

摘要："Background As the world population recovers from the COVID-19 infection, a series of acute sequelae emerge including new incident diabetes. However, the association between COVID-19 infection and new incident diabetes is not fully understood. We purpose to determine the risk of new incident diabetes after COVID-19 infection. Methods PubMed, Embase, and Cochrane Library were used as databases to search for cohort studies published from database inception to February 4, 2024. Two reviewers independently conducted the study screening, data extraction, and risk of bias assessment. A random-effects model was adopted to pool the hazard ratio (HR) with corresponding 95% confidence intervals (CI). Subgroup analysis was conducted to explore the potential influencing factors. Results A total of 20 cohort studies with over 60 million individuals were included. The pooling analysis illustrates the association between COVID-19 infection and an increased risk of new incident diabetes (HR = 1.46; 95% CI: 1.38-1.55). In subgroup analysis, the risk of type 1 diabetes was HR=1.44 (95% CI: 1.13-1.82), and type 2 diabetes was HR=1.47 (95% CI: 1.36-1.59). A slightly higher risk of diabetes was found in males (HR=1.37; 95% CI: 1.30-1.45) than in females (HR=1.29; 95% CI: 1.22-1.365). The risk of incident diabetes is associated with hospitalization: non-hospitalized patients have an HR of 1.16 (95% CI: 1.07-1.26), normal hospitalized patients have an HR of 2.15 (95% CI: 1.33-3.49), and patients receiving intensive care have the highest HR of 2.88 (95% CI: 1.73-4.79). Conclusions COVID-19 infection is associated with an elevated risk of new incident diabetes. Patients ever infected with COVID-19 should be recognized as a high-risk population with diabetes. Systematic review registration https://www.crd.york.ac.uk/prospero, identifier CRD42024522050."

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