Elevated modiolus density on high-resolution computed tomography as an indicator of cochlear neurodysplasia: a retrospective case-control study

作者全名："Zhu, Kun; Chen, Xin"

作者地址："[Zhu, Kun; Chen, Xin] Chongqing Med Univ, Dept Radiol, Childrens Hosp, 136 Zhongshan Rd 2, Chongqing 400014, Peoples R China; [Zhu, Kun; Chen, Xin] Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Minist Educ, Chongqing, Peoples R China; [Zhu, Kun; Chen, Xin] Chongqing Key Lab Pediat, Chongqing, Peoples R China; [Zhu, Kun; Chen, Xin] Chongqing Key Lab Struct Birth Defect & Reconstruc, Chongqing, Peoples R China"

通信作者："Chen, X (通讯作者)，Chongqing Med Univ, Dept Radiol, Childrens Hosp, 136 Zhongshan Rd 2, Chongqing 400014, Peoples R China.; Chen, X (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Minist Educ, Chongqing, Peoples R China.; Chen, X (通讯作者)，Chongqing Key Lab Pediat, Chongqing, Peoples R China.; Chen, X (通讯作者)，Chongqing Key Lab Struct Birth Defect & Reconstruc, Chongqing, Peoples R China."

来源：QUANTITATIVE IMAGING IN MEDICINE AND SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001312970900011

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：14

期号：8

开始页：5701

结束页：5707

文献类型：Article

关键词：Children; cochlear neurodysplasia (CND); high-resolution computed tomography (HRCT); unilateral sensorineural hearing loss; elevated modiolus density

摘要："Background: Cochlear neurodysplasia (CND) is recognized as a contributing factor to sensorineural hearing loss in children. This study aimed to investigate the relationship between modiolus density on high-resolution computed tomography (HRCT) and CND, and to evaluate its performance in diagnosing CND. Methods: This retrospective study collected HRCT images of 34 patients diagnosed with unilateral neurological hearing loss in the Children's Hospital of Chongqing Medical University from March 2018 to December 2023, who were also diagnosed with unilateral CND by computed tomography (CT) and magnetic resonance imaging (MRI) hydroimaging. CT values of the modiolus and petrous bone were measured on the affected and healthy sides, in addition to determining the width of cochlear nerve foramina and the width of internal auditory tract. The receiver operator characteristic (ROC) curve was used to evaluate the diagnostic performance of these features. Simultaneously, comparisons were conducted with parameters obtained from normal children. A total of 29 patients without CND were randomly selected as a control group. Results: The unilateral sensorineural hearing loss group had 34 patients, comprising 18 males and 16 females, with a median age of 4.5 years, ranging from 0.7 to 11 years. The normal children group consisted of 20 males and 9 females, with a median age of 5.9 years, ranging from 0.5 to 12.0 years. Statistically significant differences were observed in the CT values of the modiolus, modiolus/petrous bone CT value ratio, width of cochlear nerve foramina, and width of internal auditory tract between the affected and healthy sides in patients with unilateral sensorineural hearing loss (P<0.05). The area under the ROC curve (AUC) of the modiolus CT value and the width of cochlear nerve foramina for the diagnosis of unilateral sensorineural hearing loss was 0.98 [95% confidence interval (CI): 0.95-1.00] and 0.99 (95% CI: 0.98-1.00), respectively. the modiolus density was significantly elevated in the affected sides in patients with unilateral CND. The optimal cut-off value of modiolus CT values was 983 Hounsfield unit (HU). Conclusions: The elevated density of the modiolus on HRCT holds significant value in diagnosing CND."

基金机构：　

基金资助正文：Acknowledgments Funding: None.