Comprehensive pan-cancer analysis reveals CDC6 as a potential immunomodulatory agent and promising therapeutic target in pancreatic cancer

作者全名："Pu, Dongyao; Xu, Yingkun; Yu, Haochen; Yang, Ting; Tang, Lingfeng; Tan, Wenhao; Zhang, Wenjie; Liu, Shengchun"

作者地址："[Pu, Dongyao; Xu, Yingkun; Yu, Haochen; Tang, Lingfeng; Tan, Wenhao; Zhang, Wenjie; Liu, Shengchun] Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Yixueyuan Rd 1, Chongqing 400016, Peoples R China; [Xu, Yingkun] Shandong Univ, Dept Gen Surg, Qilu Hosp, Jinan, Peoples R China; [Yang, Ting] Chongqing Med Univ, Women & Childrens Hosp, Dept Breast & Thyroid Surg, Chongqing, Peoples R China"

通信作者："Pu, DY; Liu, SC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Yixueyuan Rd 1, Chongqing 400016, Peoples R China."

来源：TRANSLATIONAL CANCER RESEARCH

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001318839200003

JCR分区：Q4

影响因子：0.9

年份：2024

卷号：13

期号：8

开始页：4096

结束页：4112

文献类型：Article

关键词：CDC6; immune infiltration; pancreatic cancer; pan-cancer analysis; therapeutic target

摘要："Background: CDC6 is critical in DNA replication initiation, but its expression patterns and clinical implications in cancer are underexplored. This study uses multi-omics data from The Cancer Genome Atlas (TCGA) to comprehensively analyze CDC6 across various cancers, aiming to evaluate its potential as a prognostic biomarker and explore its role in immunotherapy. Methods: By leveraging multi-omics data from TCGA, we conducted a comprehensive analysis of CDC6 expression across a variety of cancer types. Least absolute shrinkage and selection operator (LASSO) regression was employed to assess the association of CDC6 with key molecules implicated in pancreatic cancer. Results: CDC6 expression was found to be significantly upregulated across a broad spectrum of cancers. High levels of CDC6 expression were associated with poor prognosis in several cancer types. Notable associations were observed between CDC6 expression and tumor mutational burden (TMB), microsatellite instability (MSI), as well as immune cell infiltration. Co-expression analysis revealed significant associations between CDC6 and prevalent immune checkpoint genes. A risk model incorporating CDC6-related genes, including CCNA1, CCNA2, CCND1, CCND2, CDC25B, CDC6, and CDK2, was developed for pancreatic cancer. Conclusions: CDC6 emerges as a promising prognostic biomarker and a potential target for immunotherapy across various cancers, including pancreatic cancer. It appears to modulate immune responses across cancer types, highlighting its regulatory role. Further exploration into the biological functions and clinical implications of CDC6 is warranted."

基金机构：Key Research and Development Project of Chongqing's Technology Innovation and Application Development Special Big Health Field [CSTC2 02 1jscx-gksb-N002 7]; Doctoral Research Innovation Project of the First Affiliated Hospital of Chongqing Medical University [CYYY-BSYJSCXXM-202213]

基金资助正文：This research was funded by the Key Research and Development Project of Chongqing's Technology Innovation and Application Development Special Big Health Field (Grant No. CSTC2 02 1jscx-gksb-N002 7) and the Doctoral Research Innovation Project of the First Affiliated Hospital of Chongqing Medical University (Grant No. CYYY-BSYJSCXXM-202213) .