Association between sleep traits and risk of colorectal cancer: a bidirectional Mendelian randomization study

作者全名："He, Fan; Yang, Fuyu; Tang, Chenglin; Chen, Defei; Xiong, Junjie; Zou, Yu; Zhao, Dongqin; Peng, Dong; Qian, Kun"

作者地址："[He, Fan; Yang, Fuyu; Tang, Chenglin; Chen, Defei; Xiong, Junjie; Zou, Yu; Zhao, Dongqin; Peng, Dong; Qian, Kun] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Peng, D; Qian, K (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF GASTROINTESTINAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001334409000017

JCR分区：Q3

影响因子：2.1

年份：2024

卷号：15

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：Colorectal cancer (CRC); sleep traits; Mendelian randomization (MR); sleep duration; genome-wide association study (GSWS)

摘要："Background: Sleep traits have been linked to diseases; particularly, their impact on cancer has received increasing attention. This study aimed to investigate whether sleep traits have a causal relationship with colorectal cancer (CRC) using two-sample Mendelian randomization (TSMR). Methods: Genetic instrumental variables (IVs) for seven sleep traits (sleep duration, ease of getting up in the morning, morning chronotype, daytime napping, insomnia symptoms, snoring, and daytime dozing) were selected from pooled data from published genome-wide association studies (GSWSs). Two-sample multivariate Mendelian randomization (MR) analyses were conducted to assess the causal association between sleep traits and CRC. Reverse MR analyses were performed to determine the causal relationship between CRC and sleep traits. Inverse variance weighted (IVW), MR-Egger, and weighted medians were calculated for all MR analyses. Results: The multivariable MR (MVMR) analysis found that appropriate sleep duration [odds ratio (OR) =0.989; 95% confidence interval (CI): 0.980, 0.999; P=0.04] and ease of getting up in the morning (OR =0.990; 95% CI: 0.980, 1.000; P=0.04) were protective factors for CRC. Snoring (OR =1.021; 95% CI: 1.002, 1.041; P=0.03) was associated with the risk of CRC. Ease of getting up in the morning (OR =0.990; 95% CI: 0.983, 0.997; P=0.003) was associated with reduced risk of colon cancer. Morning chronotype (OR =1.004; 95% CI: 1.000, 1.007; P=0.04) was associated with the risk of colon cancer. Insomnia symptoms (OR =0.995; 95% CI: 0.990, 0.999; P=0.03) were a protective factor for rectal cancer. There was no evidence found for a causal association between other sleep traits and CRC, colon, or rectal cancer. Conclusions: Proper sleep duration and ease of getting up in the morning may be protective factors against CRC, and snoring may increase the risk of CRC."

基金机构：　

基金资助正文：This research was supported by the Health Appropriate Technology Promotion Project of 2023 Chongqing (No. 2023jstg023) .